Safety and Immunogenicity of the Attenuated Yellow Fever Vaccine in Several Neotropical Primate Species

被引：0

作者：

Paula, Nayara Ferreira de ^{[1
]}

Vieira, Andre Duarte ^{[1
]}

dos Santos, Daniel Oliveira ^{[1
]}

de Souza, Lucas dos Reis ^{[1
]}

Coelho, Carlyle Mendes ^{[2
]}

Tinoco, Herlandes Penha ^{[2
]}

Lima, Paula Cristina Senra ^{[2
]}

Motta, Rafael Otavio Cancado ^{[2
]}

Pereira, Valeria do Socorro ^{[2
]}

de Carvalho, Marcelo Pires Nogueira ^{[1
]}

Fernandes, Camilla Bayma ^{[3
]}

Azevedo, Adriana de Souza ^{[3
]}

Arruda, Matheus Soares ^{[4
]}

Costa, Thais Alkifeles ^{[4
]}

Drumond, Betania Paiva ^{[4
]}

Leme, Fabiola de Oliveira Paes ^{[1
]}

Freire, Marcos da Silva ^{[3
]}

da Paixao, Tatiane Alves ^{[5
]}

Oliveira, Ayisa Rodrigues ^{[1
]}

Santos, Renato Lima ^{[1
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Escola Vet, Dept Clin & Cirurgia Vet, Ave Antonio Carlos 6627, BR-30123970 Belo Horizonte, Brazil

[2] Fundacao Parques Municipais & Zoobot, Jardim Zoolog, Ave Otacilio Negrao Lima 8000, BR-31365450 Belo Horizonte, Brazil

[3] Fundacao Oswaldo Cruz, Inst Tecnol Imunobiol Bio Manguinhos, Ave Brasil 4365, BR-21040900 Rio De Janeiro, Brazil

[4] Univ Fed Minas Gerais UFMG, Inst Ciencias Biol, Dept Microbiol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, Brazil

[5] Univ Fed Minas Gerais UFMG, Inst Ciencias Biol, Dept Patol Geral, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, Brazil

来源：

VACCINES | 2025年 / 13卷 / 05期

关键词：

flavivirus; yellow fever virus; yellow fever; 17DD; non-human primates; vaccination; RNAemia; neutralizing antibodies; VIRUS; 17DD;

D O I：

10.3390/vaccines13050487

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background/Objective: Yellow fever (YF) is an acute infectious disease caused by the yellow fever virus which is transmitted by mosquitoes. Neotropical primates are susceptible to infection, which is often presented as epizootic outbreaks. The aim was to evaluate and characterize the immune response against YF in different species of neotropical primates from the Belo Horizonte Zoo. Methods: Vaccine 17DD was administered to 24 neotropical primates, with a single subcutaneous dose. Clinical exams, RNAemia, and detection of IgG and neutralizing antibodies against YFV were performed. In addition, an ethogram was performed to assess clinical changes and animal welfare. Results: At 4 days post-vaccination, RNAemia was detected in nine animals. There was seroconversion and persistence of immune response in Alouatta guariba clamitans, Sapajus xanthosternos, Saguinus imperator and Aotus infulatus. However, the vaccine was not immunogenic for Lagothrix cana. In Pithecia irrorata seroconversion did not persist long term, while the Ateles sp. had a transient immune response. No significant clinical manifestations were observed in any of the vaccinated animals. Conclusions: This study demonstrated a safe, immunogenic and persistent immune response induced by the attenuated 17DD vaccine strain in A. guariba clamitans, S. xanthosternos, S. imperator, and A. infulatus.

引用

页数：14

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