Prevalence and indicators of cure of Italian women with vulvar squamous cell carcinoma: A population-based study

被引：2

作者：

Bucchi, Lauro ^{[1
]}

Giudici, Fabiola ^{[2
]}

Toffolutti, Federica ^{[2
]}

De Paoli, Angela ^{[5
]}

Mancini, Silvia ^{[1
]}

Preti, Mario ^{[4
]}

Gatta, Gemma ^{[3
,5
]}

Ferretti, Stefano ^{[6
]}

Crocetti, Emanuele ^{[2
]}

Fiore, Anna Rita ^{[3
]}

Bidoli, Ettore ^{[2
]}

Caldarella, Adele ^{[7
]}

Falcini, Fabio ^{[1
]}

Gili, Alessio ^{[8
]}

Cuccaroi, Francesco ^{[9
]}

Gambinoj, Maria Letizia ^{[10
]}

Casella, Claudia ^{[11
]}

Cavallo, Rossella ^{[12
]}

Ferrante, Margherita ^{[13
]}

Migliore, Enrica ^{[14
,15
]}

Carrozzi, Giuliano ^{[16
]}

Musolino, Antonino ^{[17
]}

Mazzucco, Walter ^{[18
]}

Gasparotti, Cinzia ^{[19
]}

Fusco, Mario ^{[20
]}

Ballotari, Paola ^{[21
]}

Sampietro, Giuseppe ^{[22
]}

Mangone, Lucia ^{[23
]}

Mantovani, William ^{[24
]}

Cascone, Giuseppe ^{[25
]}

Miany, Michael ^{[26
,27
]}

Manzoniz, Federica ^{[28
]}

Pesce, Maria Teresa ^{[29
]}

Galasso, Rocco ^{[30
]}

Bella, Francesca ^{[31
]}

Seghini, Pietro ^{[32
]}

Fanetti, Anna Clara ^{[33
]}

Piras, Daniela ^{[34
]}

Pinna, Pasquala ^{[35
]}

Serraino, Diego ^{[2
]}

Guzzinati, Stefano ^{[3
]}

Dal Maso, Luigino ^{[2
]}

AIRTUM Working Grp

机构：

[1] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Romagna Unit, Emilia Romagna Canc Registry, Meldola, Forli, Italy

[2] Ctr Riferimento Oncol Aviano CRO IRCCS, Canc Epidemiol Unit, Aviano, Italy

[3] Azienda Zero, Epidemiol Dept, Padua, Italy

[4] Univ Torino, Dept Surg Sci, Turin, Italy

[5] Fdn IRCCS Ist Nazl Tumori, Dept Epidemiol & Data Sci, Evaluat Epidemiol Unit, Milan, Italy

[6] Univ Ferrara, Emilia Romagna Canc Registry, Local Hlth Author, Ferrara Unit, Ferrara, Italy

[7] Inst Canc Res Prevent & Clin Network ISPRO, Tuscany Canc Registry, Clin Epidemiol Unit, Florence, Italy

[8] Univ Perugia, Dept Med & Surg, Publ Hlth Sect, Umbria Canc Registry, Perugia, Italy

[9] Local Hlth Unit Barletta Andria Trani, Sect Canc Registry Puglia, Barletta, Italy

[10] Registro Tumori ATS Insubria Prov Como & Varese Re, Varese, Italy

[11] IRCCS Osped Policlin San Martino, Liguria Canc Registry, Genoa, Italy

[12] Registro Tumori ASL Salerno, Dipartimento Prevenz, Salerno, Italy

[13] Azienda Osped Univ Policlin G Rodolico San Marco, UOC Igiene Osped, Registro Tumori Integrato CT ME EN, Catania, Italy

[14] CPO Piemonte, Piedmont Canc Registry, Turin, Italy

[15] Univ Turin, Turin, Italy

[16] Local Hlth Author, Publ Hlth Dept, Modena Unit, Emilia Romagna Canc Registry, Modena, Italy

[17] Univ Parma, Univ Hosp Parma, Emilia Romagna Canc Registry, Med Oncol,Dept Med & Surg,Parma Unit, Parma, Italy

[18] Azienda Osped Univ Policlin AOUP Palermo, Clin epidemiol & Canc Registry Unit, Palermo, Italy

[19] ATS Brescia Canc Registry, Struttura Semplice Epidemiol, Brescia, Italy

[20] UOSD Registro Tumori ASL Napoli 3 Sud, Naples, Italy

[21] ATS Val Padana, SC Osservatorio Epidemiol, Mantua, Italy

[22] Agenzia Tutela Salute, Epidemiol Serv, Bergamo Canc Registry, Bergamo, Italy

[23] Azienda Unita Sanit Locale IRCCS Reggio Emilia, Reggio Emilia Unit, Epidemiol Unit, Emilia Romagna Canc Registry, Reggio Emilia, Italy

[24] Local Hlth Author, Clin & Evaluat Epidemiol Unit, Trento Prov Canc Registry, Trento, Italy

[25] Azienda Sanit Prov Ragusa UOSD Registro Tumori, Ragusa, Italy

[26] Paracelsus Med Private Univ PMU, Innovat Res & Teaching Serv SABES ASDAA, Teaching Hosp, Bolzano, Italy

[27] Coll Hlth Care Profess Claudiana, Bolzano, Italy

[28] Hlth Protect Agcy Pavia, Epidemiol Unit, Pavia, Italy

[29] Monitoraggio Rischio Ambientale & Registro Tumori, Caserta, Italy

[30] IRCCS CROB, Unit Reg Canc Registry, Clin Epidemiol & Biostat, Rionero In Vulture, Italy

[31] Prov Hlth Author Siracusa, Siracusa Canc Registry, Siracusa, Italy

[32] Unit Epidemiol AUSL Piacenza, Piacenza Unit, Emilia Romagna Canc Registry, Piacenza, Italy

[33] Agenzia Tutela Salute Montagna Canc Registry, Sondrio, Italy

[34] ASL Sassari, Nord Sardegna Canc Registry, Sassari, Italy

[35] ASL Nuoro, Nuoro Canc Registry, Nuoro, Italy

来源：

EJSO | 2025年 / 51卷 / 04期

关键词：

Vulvar squamous cell carcinoma; Cancer survivors; Complete prevalence; Cure fraction; Long-term survival; Cancer registries; CANCER; SURVIVAL; TRENDS; KNOWLEDGE; MORTALITY; NEOPLASIA; SOCIETY;

D O I：

10.1016/j.ejso.2024.108707

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: Five-year net survival and conditional survival from vulvar squamous cell carcinoma (VSCC) patients in Italy have shown no progress during the past three decades. This study aims to estimate the complete prevalence and multiple indicators of cure. Methods: Observed prevalence was estimated using 31 Italian cancer registries covering 47 % of Italian women. A subset of 22 cancer registries was used to estimate model-based long-term survival and indicators of cure, i.e., complete prevalence, cure fraction (CF), time to cure (TTC), proportion of 'already cured' patients, and cure prevalence. Results: In 2018, VSCC patients alive in Italy (complete prevalence) were 6620 or 22 per 100,000 women. The cure fraction (the proportion of newly diagnosed patients who will not die of VSCC) did not change between 2000 and 2010 both for all patients (32 %) and in each age group. The time to cure (5-year conditional net survival >95 %) was 11 years for patients aged >44 years, but excess mortality remained for >15 years in the other age groups. This led to a negligible (5 %) proportion of 'already cured' patients (living longer than time to cure). The proportion of patients alive <2 years (21 %) was the same as that of patients surviving >15 years. The cure prevalence (patients who will not die of VSCC) was 64 %. A considerable proportion of patients will not be cured even among those who survived >5 years. Conclusion: There is an urgent need to reshape the current vulvar care model in Italy.

引用

页数：6

共 34 条

[1]

AIRTUM Working Group, 2016, Epidemiol Prev, V40, P1, DOI 10.19191/EP16.1S2.P001.035

[2] Trends in incidence and survival of women with invasive vulvar cancer in the United States and Canada: A population-based study [J].

Akhtar-Danesh, Noori ;

Elit, Laurie ;

Lytwyn, Alice .

GYNECOLOGIC ONCOLOGY, 2014, 134 (02) :314-318

[3] The International Society for the Study of Vulvovaginal Disease (ISSVD) Vulvar Awareness Day Campaign: Knowledge of Vulvovaginal Diseases Among Italian Obstetrics and Gynecology Residents [J].

Bevilacqua, Federica ;

Selk, Amanda ;

Stockdale, Colleen ;

Vieira-Baptista, Pedro ;

Adedipe, Tolu ;

Bohl, Tanja ;

Marozio, Luca ;

Borella, Fulvio ;

Gallio, Niccolo ;

Pollano, Benedetta ;

Robba, Eleonora ;

Barbierato, Ilaria ;

Benedetto, Chiara ;

Preti, Mario .

JOURNAL OF LOWER GENITAL TRACT DISEASE, 2024, 28 (01) :91-94

[4] Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].

Bray, Freddie ;

Laversanne, Mathieu ;

Sung, Hyuna ;

Ferlay, Jacques ;

Siegel, Rebecca L. ;

Soerjomataram, Isabelle ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2024, 74 (03) :229-263

[5] Centralization of care for patients with advanced-stage ovarian cancer - A cost-effectiveness analysis [J].

Bristow, Robert E. ;

Santillan, Antonio ;

Diaz-Montes, Teresa R. ;

Gardner, Ginger I. ;

Giuntoli, Robert L., II ;

Meisner, Benjamin C. ;

Frick, Kevin D. ;

Armstrong, Deborah K. .

CANCER, 2007, 109 (08) :1513-1522

[6] New Insights into the Epidemiology of Vulvar Cancer: Systematic Literature Review for an Update of Incidence and Risk Factors [J].

Bucchi, Lauro ;

Pizzato, Margherita ;

Rosso, Stefano ;

Ferretti, Stefano .

CANCERS, 2022, 14 (02)

[7] Cancer cure for 32 cancer types: results from the EUROCARE-5 study [J].

Dal Maso, Luigino ;

Panato, Chiara ;

Tavilla, Andrea ;

Guzzinati, Stefano ;

Serraino, Diego ;

Mallone, Sandra ;

Botta, Laura ;

Boussari, Olayide ;

Capocaccia, Riccardo ;

Colonna, Marc ;

Crocetti, Emanuele ;

Dumas, Agnes ;

Dyba, Tadek ;

Franceschi, Silvia ;

Gatta, Gemma ;

Gigli, Anna ;

Giusti, Francesco ;

Jooste, Valerie ;

Minicozzi, Pamela ;

Neamtiu, Luciana ;

Romain, Gaelle ;

Zorzi, Manuel ;

De Angelis, Roberta ;

Francisci, Silvia .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2020, 49 (05) :1517-1525

[8] Differentiated vulvar intraepithelial neoplasia long-term follow up and prognostic factors: An analysis of a large historical cohort [J].

Gallio, Niccolo ;

Preti, Mario ;

Jones, Ronald W. ;

Borella, Fulvio ;

Woelber, Linn ;

Bertero, Luca ;

Urru, Sara ;

Micheletti, Leonardo ;

Zamagni, Federica ;

Bevilacqua, Federica ;

Tondo, Pierluigi ;

Pollano, Benedetta ;

Cassoni, Paola ;

Benedetto, Chiara .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2024, 103 (06) :1175-1182

[9] Rare cancers are not so rare: The rare cancer burden in Europe [J].

Gatta, Gemma ;

van der Zwan, Jan Maarten ;

Casali, Paolo G. ;

Siesling, Sabine ;

Dei Tos, Angelo Paolo ;

Kunkler, Ian ;

Otter, Renee ;

Licitra, Lisa ;

Mallone, Sandra ;

Tavilla, Andrea ;

Trama, Annalisa ;

Capocaccia, Riccardo .

EUROPEAN JOURNAL OF CANCER, 2011, 47 (17) :2493-2511

[10] Indicators of cure for women living after uterine and ovarian cancers: a population-based study [J].

Giudici, Fabiola ;

De Paoli, Angela ;

Toffolutti, Federica ;

Guzzinati, Stefano ;

Francisci, Silvia ;

Bucchi, Lauro ;

Gatta, Gemma ;

Demuru, Elena ;

Mallone, Sandra ;

Cin, Antonella Dal ;

Caldarella, Adele ;

Cuccaro, Francesco ;

Migliore, Enrica ;

Gambino, Maria Letizia ;

Ravaioli, Alessandra ;

Puppo, Antonella ;

Ferrante, Margherita ;

Carrozzi, Giuliano ;

Stracci, Fabrizio ;

Musolino, Antonino ;

Gasparotti, Cinzia ;

Cavallo, Rossella ;

Mazzucco, Walter ;

Vitale, Maria Francesca ;

Cascone, Giuseppe ;

Ballotari, Paola ;

Ferretti, Stefano ;

Mangone, Lucia ;

Rizzello, Roberto Vito ;

Sampietro, Giuseppe ;

Mian, Michael ;

Boschetti, Lorenza ;

Galasso, Rocco ;

Bella, Francesca ;

Piras, Daniela ;

Sessa, Alessandra ;

Seghini, Pietro ;

Fanetti, Anna Clara ;

Pinna, Pasquala ;

De Angelis, Roberta ;

Serraino, Diego ;

Dal Maso, Luigino .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2024, 193 (09) :1224-1232

← 1 2 3 4 →