Gliomagenesis following chronic subdural hematoma: A case report

The occurrence of subdural hematoma following brain tumor surgery is rare, with glioma-associated subdural hematoma only sporadically documented in the literature. However, to the best of our knowledge, reports of the occurrence of gliomagenesis following subdural hematoma have remained scarce. The present study delineates a case of left frontal gliomagenesis that developed within a brief period following the occurrence of a subdural hematoma in the left frontal and temporal lobes. Specifically, a 62-year-old male patient with a 7-month history of subdural hematoma presented with a large solid-occupying lesion centered in the left frontal lobe. Histological examination revealed the lesion to be a diffuse glioma. The patient exhibited a favorable recovery subsequent to the evacuation of the subdural hematoma and administration of routine medication. However, a neighboring brain tumor developed rapidly 5 months later, which was excised by surgical intervention and submitted for pathological examination. The results demonstrated that the tumor was a grade IV glioma. Conventional radiotherapy for glioma was then administered to the patient. Given the tumor's aggressive profile, the patient remains at elevated risk for recurrence and metastasis. At the 1-month postoperative evaluation, the patient was clinically stable with maintained independence in activities of daily living (ADLs), including household chores. The presented case report offers a potential indication of a causal relationship between subdural hematoma and gliomagenesis. It is plausible that subdural hematoma may be a contributing factor in the formation or rapid growth of glioma.