The Spectrum of Small Heat Shock Protein B8 (HSPB8)-Associated Neuromuscular Disorders

被引:0
作者
Rashed, Hebatallah R. [1 ,2 ]
Nath, Samir R. [1 ]
Milone, Margherita [1 ]
机构
[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
[2] Ain Shams Univ, Dept Neurol, Cairo 11588, Egypt
关键词
CASA; CTM2; CMT2L; dHMN; HMN; HSPB8; myofibrillar myopathy; myopathy; rimmed vacuoles; HEREDITARY MOTOR NEUROPATHY; MARIE-TOOTH-DISEASE; DISTAL HMN-II; HSP22; HSPB8; MOUSE MODEL; MUTATIONS; PHENOTYPE; DOMINANT; MUTANT; GENE;
D O I
10.3390/ijms26072905
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The heat shock protein B8 (HSPB8) is one of the small heat shock proteins (sHSP or HSPB) and is a ubiquitous protein in various organisms, including humans. It is highly expressed in skeletal muscle, heart, and neurons. It plays a crucial role in identifying misfolding proteins and participating in chaperone-assisted selective autophagy (CASA) for the removal of misfolded and damaged, potentially cytotoxic proteins. Mutations in HSPB8 can cause distal hereditary motor neuropathy (dHMN), Charcot-Marie-Tooth (CMT) disease type 2L, or myopathy. The disease can manifest from childhood to mid-adulthood. Most missense mutations in the N-terminal and alpha-crystallin domains of HSPB8 lead to dHMN or CMT2L. Frameshift mutations in the C-terminal domain (CTD), resulting in elongation of the HSPB8 C-terminal, cause myopathy with myofibrillar pathology and rimmed vacuoles. Myopathy and motor neuropathy can coexist. HSPB8 frameshift mutations in the CTD result in HSPB8 mutant aggregation, which weakens the CASA ability to direct misfolded proteins to autophagic degradation. Cellular and animal models indicate that HSPB8 mutations drive pathogenesis through a toxic gain-of-function mechanism. Currently, no cure is available for HSPB8-associated neuromuscular disorders, but numerous therapeutic strategies are under investigation spanning from small molecules to RNA interference to exogenous HSPB8 delivery.
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页数:16
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