Subcortical correlates of consciousness with human single neuron recordings

被引：0

作者：

Pereira, Michael ^{[1
,2
,3
,4
]}

Faivre, Nathan ^{[1
,2
,5
]}

Bernasconi, Fosco ^{[1
,2
]}

Brandmeir, Nicholas ^{[6
]}

Suffridge, Jacob E. ^{[3
,7
]}

Tran, Kaylee ^{[3
]}

Wang, Shuo ^{[3
,7
,8
]}

Finomore, Victor ^{[3
]}

Konrad, Peter ^{[6
]}

Rezai, Ali ^{[3
,6
]}

Blanke, Olaf ^{[1
,2
,9
]}

机构：

[1] Swiss Fed Inst Technol EPFL, Neurox Inst, Lab Cognit Neurosci, Geneva, Switzerland

[2] Swiss Fed Inst Technol EPFL, Brain Mind Inst, Fac Life Sci, Geneva, Switzerland

[3] WVU Rockefeller Neurosci Inst, Dept Neurosci, Morgantown, WV 26505 USA

[4] Univ Grenoble Alpes, Grenoble Inst Neurosci, INSERM, CHU Grenoble Alpes,U1216, Grenoble, France

[5] Univ Grenoble Alpes, Univ Savoie Mont Blanc, CNRS, LPNC, Grenoble, France

[6] WVU Rockefeller Neurosci Inst, Dept Neurosurg, Morgantown, WV USA

[7] West Virginia Univ, Dept Comp Sci & Elect Engn, Morgantown, WV USA

[8] Washington Univ St Louis, Dept Radiol, St Louis, MO USA

[9] Univ Hosp Geneva, Dept Clin Neurosci, Geneva, Switzerland

来源：

ELIFE | 2025年 / 13卷

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

perception; consciousness; subcortical; neuron; thalamus; subthalamic; PERCEPTUAL DECISION; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; STIMULATION; AWARENESS; SELECTION; THALAMUS;

D O I：

10.7554/eLife.95272

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subcortical brain structures such as the subthalamic nucleus or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness remains unclear, due to the inherent difficulties of recording subcortical neuronal activity in humans. Here, we asked neurological patients undergoing surgery for deep brain stimulation to detect weak vibrotactile stimuli applied on their hand while recording single neuron activity from the tip of a microelectrode. We isolated putative single neurons in the subthalamic nucleus and thalamus. A significant proportion of neurons modulated their activity while participants were expecting a stimulus. We found that the firing rate of 23% of these neurons differed between detected and undetected stimuli. Our results provide direct neurophysiological evidence of the involvement of the subthalamic nucleus and the thalamus for the detection of vibrotactile stimuli, thereby calling for a less cortico-centric view of the neural correlates of consciousness.

引用

页数：15

共 62 条

[1] The Subthalamic Nucleus: A Hub for Sensory Control via Short Three-Lateral Loop Connections with the Brainstem? [J].