Alpha-Glucosidase and Nitric Oxide Inhibitors from Paramignya trimera Leaves and Dicranopteris linearis Spores: In Silico and In Vitro Aspects

被引：0

作者：

Le, Huong Thuy ^{[1
]}

Nguyen, Tuan-Dat ^{[2
]}

Do, Anh-Ky ^{[2
]}

Nguyen, Thi-Phuong ^{[3
]}

Ngo, Thi-My-Duyen ^{[1
]}

Nguyen, Thi-Hoai-Thu ^{[4
]}

Bui, Xuan-Hao ^{[2
]}

Sichaem, Jirapast ^{[5
]}

Duong, Thuc-Huy ^{[2
]}

Nguyen, Ngoc-Hong ^{[6
]}

机构：

[1] Ton Duc Thang Univ, Fac Pharm, Res Grp Pharmaceut & Biomed Sci, Ho Chi Minh City, Vietnam

[2] Ho Chi Minh City Univ Educ, Dept Chem, Ho Chi Minh City, Vietnam

[3] Nguyen Tat Thanh Univ, NTT Hitech Inst, Ho Chi Minh City, Vietnam

[4] Univ Med & Pharm, Fac Fundamental Sci, Ho Chi Minh City, Vietnam

[5] Thammasat Univ, Fac Sci & Technol, Res Unit Nat Prod Chem & Bioact, Lampang Campus, Lampang, Thailand

[6] HUTECH Univ, CirTech Inst, Ho Chi Minh City, Vietnam

来源：

CHEMISTRY & BIODIVERSITY | 2025年

关键词：

alpha-glucosidase inhibition; anti-inflammatory activity; Dicranopteris linearis; docking study; Paramignya trimera; COUMARINS; PROTEIN; PHYTOCHEMICALS; CONSTITUENTS; DERIVATIVES; QUERCETIN; SOLVENTS; EXTRACT; ROOTS; STEMS;

D O I：

10.1002/cbdv.202500588

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dicranopteris linearis and Paramignya trimera, widely utilized plants in traditional Vietnamese medicine, lack comprehensive chemical and biological data pertaining to their composition. The crude extracts of these biosources showed remarkable alpha-glucosidase and nitric oxide (NO) inhibition. Bioguided isolation based on alpha-glucosidase inhibition and anti-inflammatory activity was applied to P. trimera and D. linearis, providing 14 metabolites. Upon evaluating the alpha-glucosidase activity of compounds 1-14, it was observed that all tested compounds exhibited significant activity, with IC50 values ranging from 22.5 to 157.7 mu M. Notably, compound 14 was identified as a new compound. Compounds 6-8 exhibited potent NO inhibitory effect in LPS-induced RAW264.7 macrophage cells, with IC50 values ranging from 26.65 to 28.79 mu g/mL.

引用

页数：11

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