Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness

被引：4

作者：

Back, Magnus ^{[1
,2
,3
]}

Xhaard, Constance ^{[1
]}

Rouget, Raphael ^{[4
]}

Thuillier, Quentin ^{[4
]}

Plunde, Oscar ^{[2
]}

Larsson, Susanna C. ^{[5
,6
]}

Girerd, Nicolas ^{[1
]}

Ferreira, Joao Pedro ^{[1
]}

Boivin, Jean-Marc ^{[1
]}

Bozec, Erwan ^{[1
]}

Merckle, Ludovic ^{[1
]}

Zannad, Faiez ^{[1
]}

Hoge, Axelle ^{[7
]}

Guillaume, Michele ^{[7
]}

Dandine-Roulland, Claire ^{[7
]}

Le Floch, Edith ^{[8
]}

Bacq-Daian, Delphine ^{[8
]}

Deleuze, Jean-Francois ^{[8
]}

Van den Berghe, Laurie ^{[9
]}

Nazare, Julie-Anne ^{[9
]}

Laville, Martine ^{[9
]}

Branlant, Christiane ^{[4
]}

Behm-Ansmant, Isabelle ^{[4
]}

Wagner, Sandra ^{[1
]}

Rossignol, Patrick ^{[1
]}

机构：

[1] Univ Lorraine, Nancy Univ Hosp, INSERM,U1116, CIC 1433,FCRIN INI CRCT, Nancy, France

[2] Karolinska Inst, Dept Med Solna, S-17176 Stockholm, Sweden

[3] Karolinska Univ Hosp Huddinge, Dept Cardiol, S-14186 Stockholm, Sweden

[4] Univ Lorraine, CNRS, UMR 7365, IMoPA, F-54000 Nancy, France

[5] Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden

[6] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden

[7] Univ Liege, Dept Sci Sante Publ, Liege, Belgium

[8] Univ Paris Saclay, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France

[9] Univ Claude Bernard Lyon1, Univ Lyon, Ctr Rech Nutr Humaine Rhone Alpes, CarMeN Lab,Hosp Civils Lyon,F CRIN FORCE Network, Lyon, France

来源：

EUROPEAN HEART JOURNAL OPEN | 2022年 / 2卷 / 02期

基金：

瑞典研究理事会;

关键词：

Arterial stiffness; Dietary; Inflammation; Omega-3 fatty acids; Prevention; STANISLAS cohort; PLASMA; PUFAS; RISK; RESOLUTION; MEDIATORS; VARIANTS; MODULATE; RATIO; FISH;

D O I：

10.1093/ehjopen/oeac016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality and cardiovascular events. The aim of the present study was to determine the association of PUFA intake, FADS1 genotype, and FADS expression with arterial stiffness.Methods and results A cross-sectional population-based cohort study of 1464 participants without overt cardiovascular disease was conducted. Dietary intake was assessed using a food frequency questionnaire. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV), and the FADS1 locus variant was determined. Blood cell transcriptomics was performed in a subset of 410 individuals. Pulse wave velocity was significantly associated with the FADS1 locus variant. Differential associations between PWV and omega-3 PUFA intake were observed depending on the FADS1 genotype. High omega-3 PUFA intake attenuated the FADS1 genotype-dependent associations. Carriers of the minor FADS1 locus variant exhibited increased expression of FADS2, which is associated with PWV.Conclusion Taken together, these findings point to FADS1 genotype-dependent associations of omega-3 PUFA intake on subclinical cardiovascular disease. These findings may have implications for identifying responders and non-responders to omega-3 PUFA supplementation and open up for personalized dietary counselling in cardiovascular prevention.

引用

页数：11

共 41 条

[21] Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes [J].