Triterpenoids with inhibitory effects on lipid accumulation from Ganoderma lucidum

被引：0

作者：

Chai, Lu ^{[1
,2
]}

Liu, Xiao-Cui ^{[1
,2
]}

Wu, Zhou-Wei ^{[1
,2
]}

Luo, Yi ^{[1
,2
]}

Tao, Xin-Yu ^{[1
,2
]}

Peng, Xing-Rong ^{[1
,2
]}

Qiu, Ming-Hua ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Nat Med, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Bioinnovat Ctr DR PLANT, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

来源：

FITOTERAPIA | 2025年 / 184卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma lucidum; Lanostane triterpenes; HepG2; cell; Lipid accumulation; FR KARST; GANOLUCIDIC ACID; CONSTITUENTS; TERPENOIDS; RESINACEUM;

D O I：

10.1016/j.fitote.2025.106585

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight undescribed lanostane-type triterpenes (1-8) and twenty-seven known analogues (9-35) were isolated from the fruiting bodies of cultivated Ganoderma lucidum. The chemical structures of these compounds were elucidated using a combination of spectroscopic techniques. Ganosinenic acid D (1) and ganosinenic acid E (2) were identified as rare pentacyclic triterpenoids with an unusual four-membered carbon ring motif. The inhibitory effects of all compounds on lipid accumulation were evaluated in oleic acid (OA)-induced HepG2 cells. Among the tested compounds, ganolucidic acid G (7), lucidenic acid N (9), methyl lucidenate M (29) showed moderate inhibitory effects. Furthermore, lucidenic acid N inhibited lipid accumulation in a dose-dependent manner. The structure-activity relationship analysis revealed enhanced efficacy in side chain-degraded C27 nor-triterpenoids compared to C24 and C30 analogs.

引用

页数：10

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