Triterpenoids with inhibitory effects on lipid accumulation from Ganoderma lucidum

被引：0

作者：

Chai, Lu ^{[1
,2
]}

Liu, Xiao-Cui ^{[1
,2
]}

Wu, Zhou-Wei ^{[1
,2
]}

Luo, Yi ^{[1
,2
]}

Tao, Xin-Yu ^{[1
,2
]}

Peng, Xing-Rong ^{[1
,2
]}

Qiu, Ming-Hua ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Nat Med, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Bioinnovat Ctr DR PLANT, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

来源：

FITOTERAPIA | 2025年 / 184卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma lucidum; Lanostane triterpenes; HepG2; cell; Lipid accumulation; FR KARST; GANOLUCIDIC ACID; CONSTITUENTS; TERPENOIDS; RESINACEUM;

D O I：

10.1016/j.fitote.2025.106585

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight undescribed lanostane-type triterpenes (1-8) and twenty-seven known analogues (9-35) were isolated from the fruiting bodies of cultivated Ganoderma lucidum. The chemical structures of these compounds were elucidated using a combination of spectroscopic techniques. Ganosinenic acid D (1) and ganosinenic acid E (2) were identified as rare pentacyclic triterpenoids with an unusual four-membered carbon ring motif. The inhibitory effects of all compounds on lipid accumulation were evaluated in oleic acid (OA)-induced HepG2 cells. Among the tested compounds, ganolucidic acid G (7), lucidenic acid N (9), methyl lucidenate M (29) showed moderate inhibitory effects. Furthermore, lucidenic acid N inhibited lipid accumulation in a dose-dependent manner. The structure-activity relationship analysis revealed enhanced efficacy in side chain-degraded C27 nor-triterpenoids compared to C24 and C30 analogs.

引用

页数：10

共 36 条

[1] SpecDis: Quantifying the Comparison of Calculated and Experimental Electronic Circular Dichroism Spectra [J].

Bruhn, Torsten ;

Schaumloeffel, Anu ;

Hemberger, Yasmin ;

Bringmann, Gerhard .

CHIRALITY, 2013, 25 (04) :243-249

[2] Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase [J].

Chen, Xian-Qiang ;

Zhao, Jing ;

Chen, Ling-Xiao ;

Wang, Shen-Fei ;

Wang, Ying ;

Li, Shao-Ping .

PHYTOCHEMISTRY, 2018, 149 :103-115

[3] Ganoderic acid A holds promising cytotoxicity on human glioblastoma mediated by incurring apoptosis and autophagy and inactivating PI3K/AKT signaling pathway [J].

Cheng, Yong ;

Xie, Peng .

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 33 (11)

[4]

Chiu H.-F., Pharm. Biol., V55

[5] Anti-Lung Cancer Activity through Enhancement of Immunomodulation and Induction of Cell Apoptosis of Total Triterpenes Extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst. [J].

Feng, Liang ;

Yuan, Ling ;

Du, Meng ;

Chen, Yan ;

Zhang, Ming-Hua ;

Gu, Jun-Fei ;

He, Jun-Jie ;

Wang, Ying ;

Cao, Wei .

MOLECULES, 2013, 18 (08) :9966-9981

[6]

Guo D., 2007, Method for Preparing Triterpene Compounds from Powdery Traditional Chinese Medicine Containing Ganoderma Lucidum

[7] Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum [J].

Hardy, Timothy ;

Oakley, Fiona ;

Anstee, Quentin M. ;

Day, Christopher P. .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11, 2016, 11 :451-496

[8] Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation [J].

Iwatsuki, K ;

Akihisa, T ;

Tokuda, H ;

Ukiya, M ;

Oshikubo, M ;

Kimura, Y ;

Asano, T ;

Nomura, A ;

Nishino, H .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (12) :1582-1585

[9] Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia [J].

Jiao, Yang ;

Xie, Ting ;

Zou, Lu-Hui ;

Wei, Qian ;

Qiu, Li ;

Chen, Li-Xia .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (15) :3556-3561

[10]

KIKUCHI T, 1986, CHEM PHARM BULL, V34, P3695

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