Impact of mepolizumab on the AAV-PRO questionnaire in eosinophilic granulomatosis with polyangiitis: data from a European multicentre study

被引：1

作者：

Delvino, Paolo ^{[1
,2
]}

Quartuccio, Luca ^{[3
]}

Robson, Joanna C. ^{[4
,5
]}

Ferretti, Virginia V. ^{[6
]}

Klersy, Catherine ^{[6
]}

Alberici, Federico ^{[7
,8
]}

Bagnasco, Diego ^{[9
]}

Berti, Alvise ^{[10
,11
]}

Caminati, Marco ^{[8
,12
,13
,14
]}

Camoni, Marta ^{[7
]}

Cid, Maria C. ^{[15
]}

Conticini, Edoardo ^{[16
]}

Costanzo, Giulia ^{[17
]}

de Moreuil, Claire ^{[18
]}

Del Giacco, Stefano ^{[17
]}

Espigol-Frigole, Georgina ^{[15
]}

Franceschini, Franco ^{[19
,20
]}

Iorio, Luca ^{[21
]}

Kernder, Anna ^{[22
,23
,24
]}

Lo Gullo, Alberto ^{[25
]}

Losappio, Laura ^{[26
]}

Manna, Elena ^{[27
,28
]}

Maule, Matteo ^{[12
,13
,14
]}

Milanesi, Alessandra ^{[27
,28
,29
]}

Montecucco, Carlomaurizio ^{[27
,28
]}

Negrini, Simone ^{[30
,31
]}

Padoan, Roberto ^{[21
]}

Regola, Francesca ^{[19
,20
]}

Ricciardi, Luisa ^{[32
]}

Schroeder, Jan ^{[26
]}

Terrier, Benjamin ^{[33
,34
]}

Toniati, Paola ^{[19
]}

Torracca, Francesca ^{[35
]}

Treppo, Elena ^{[3
]}

Urban, Maria Letizia ^{[36
]}

Vaglio, Augusto ^{[37
,38
]}

Emmi, Giacomo ^{[39
,40
]}

Monti, Sara ^{[41
]}

机构：

[1] Univ Milano Bicocca, Sch Med & Surg, I-20126 Milan, Italy

[2] Fdn IRCSS San Gerardo Tintori, Rheumatol Unit, Monza, Italy

[3] Univ Udine, Acad Hosp Santa Maria Misericordia, Dept Med DMED, Div Rheumatol,ASUFC, Udine, Italy

[4] Univ West England, Sch Hlth & Social Wellbeing, Bristol, England

[5] Univ Hosp Bristol & Weston NHS Fdn Trust, Rheumatol Dept, Bristol, England

[6] Fdn IRCCS Policlin San Matteo, Biostat & Clin Trial Ctr, Pavia, Italy

[7] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy

[8] ASST Spedali Civili Brescia, Spedali Civili Hosp, Nephrol Unit, Brescia, Italy

[9] Univ Genoa, Dept Internal Med DIMI, Allergy & Resp Dis, IRCCS Policlin San Martino, Genoa, Italy

[10] Univ Trento, Ctr Med Sci CISMed, Dept Cellular Computat & Integrat Biol CIBIO, Trento, Italy

[11] Santa Chiara Hosp, APSS, Unit Rheumatol, Trento, Italy

[12] Univ Verona, Dept Med, Verona, Italy

[13] Verona Integrated Univ Hosp, Asthma Ctr, Verona, Italy

[14] Verona Integrated Univ Hosp, Allergy Unit, Verona, Italy

[15] Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Dept Autoimmune Dis, Barcelona, Spain

[16] Univ Siena, Dept Med Surg & Neurosci, Rheumatol Unit, Siena, Italy

[17] Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy

[18] CHU Brest, Dept Internal Med, GETBO, UMR 1304, Brest, France

[19] ASST Spedali Civili Brescia, Dipartimento Continuita Cure & Fragil, Rheumatol & Clin Immunol Unit, Brescia, Italy

[20] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy

[21] Univ Padua, Dept Med DIMED, Div Rheumatol, Padua, Italy

[22] Heinrich Heine Univ, Univ Hosp Dusseldorf, Med Fac, Clin Rheumatol, Dusseldorf, Germany

[23] Heinrich Heine Univ, Univ Hosp Dusseldorf, Hiller Res Ctr, Med Fac, Dusseldorf, Germany

[24] Ruhr Univ Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany

[25] Arnas Garibaldi Hosp, Rheumatol Unit, Catania, Italy

[26] ASST GOM Niguarda, Div Allergy & Clin Immunol, Milan, Italy

[27] Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy

[28] Fdn IRCCS Policlin San Matteo, Div Rheumatol, Pavia, Italy

[29] Univ Pavia, Expt Med, Pavia, Italy

[30] IRCCS Osped Policlin San Martino, Clin Immunol & Translat Med Unit, Internal Med, Genoa, Italy

[31] Univ Genoa, Dept Internal Med DIMI, Genoa, Italy

[32] Univ Messina, G Martino Teaching Hosp, Dept Clin & Expt Med, Allergy & Immunol Unit, Messina, Italy

[33] Hop Cochin, Natl Referral Ctr Rare Syst Autoimmune Dis, Dept Internal Med, Paris, France

[34] Paris Cite Univ, Paris, France

[35] APACS APS ETS Assoc Pazienti Sindrome Churg Straus, Arosio, Italy

[36] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[37] Univ Firenze, Dept Biomed Expt & Clin Sci Mario Serio, Florence, Italy

[38] Meyer Childrens Hosp IRCCS, Nephrol & Dialysis Unit, Florence, Italy

[39] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[40] Cattinara Univ Hosp, Clin Med & Rheumatol Unit, Trieste, Italy

[41] IRCCS Ist Auxol Italiano, Immunorheumatol Res Lab, Milan, Italy

来源：

RHEUMATOLOGY | 2025年

关键词：

eosinophilic granulomatosis with polyangiitis; mepolizumab; health-related quality of life; patient-reported outcomes; ANCA-associated vasculitis patient-reported outcomes questionnaire; CHURG-STRAUSS-SYNDROME; RHEUMATOLOGY CLASSIFICATION CRITERIA; 2022; AMERICAN-COLLEGE; QUALITY-OF-LIFE; TERM-FOLLOW-UP; ASSOCIATIONS; ALLIANCE; TRIALS;

D O I：

10.1093/rheumatology/keaf232

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To prospectively evaluate the impact and the rapidity of the effect of mepolizumab on the ANCA-associated vasculitis patient-reported outcomes (AAV-PRO) questionnaire and patient global assessment (PtGA) in an international, multicentre cohort of patients with eosinophilic granulomatosis with polyangiitis (EGPA).Methods Patients with active EGPA initiating treatment with mepolizumab were included. PtGA and the AAV-PRO score were assessed at baseline and after 7, 14, 30, 90 and 180 days. Predictors of response of the AAV-PRO questionnaire were investigated.Results Seventy patients were included: female 54.3%, median age 56 years (48-65), 63 (90%) with a relapsing/refractory course. PtGA showed a statistically significant decrease within 7 days. At 14 days, all the AAV-PRO domains, except treatment side effects, showed a statistically significant decline. The improvement at 6 months was greatest in organ-specific symptoms (ratio 0.53), physical function (ratio 0.57) and PtGA (ratio 0.58). PtGA and higher disease activity positively correlated with the AAV-PRO scores throughout the study. Female patients reported a greater burden in terms of systemic symptoms, treatment side effects, social and emotional impact and concerns about the future. Conversely, age, educational level, damage accrual, mepolizumab dose and ANCA status had no effect on the AAV-PRO scores.Conclusions Mepolizumab was associated with a quick and remarkable improvement of health-related quality of life in patients with EGPA. These findings highlight its early and sustained benefits beyond disease control and support the integration of the AAV-PRO questionnaire into routine clinical practice.

引用

页数：11

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