Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019

被引：0

作者：

Liu, Xiao ^{[1
,2
,3
]}

Wu, Yuting ^{[4
]}

Li, Fei ^{[5
]}

Qi, Xinrui ^{[4
]}

Niu, Liyan ^{[4
]}

Wu, Yifan ^{[4
]}

Ling, Jitao ^{[4
]}

Zhu, Wengen ^{[6
]}

Li, Qingqing ^{[4
]}

Liu, Xinyu ^{[7
]}

Zhang, Jing ^{[8
]}

Shen, Yunfeng ^{[9
]}

Yan, Zhiwei ^{[10
]}

Zhang, Deju ^{[11
]}

Wang, Jingfeng ^{[1
]}

Zhang, Yuling ^{[1
]}

Yu, Peng ^{[4
]}

机构：

[1] Sun Yat Sen Univ, Dept Cardiol, Sun Yat Sen Mem Hosp, Guangzhou 510080, Guangdong, Peoples R China

[2] Guangdong Hong Kong Joint Lab RNA Med, Guangzhou Key Lab Mol Mech & Translat Major Cardi, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Guangdong, Peoples R China

[3] Nanchang Univ, Affiliated Hosp 2, Inst Study Endocrinol & Metab Jiangxi Prov, Nanchang, Peoples R China

[4] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Endocrinol Med, Nanchang 330008, Jiangxi, Peoples R China

[5] Fourth Peoples Hosp, Dept Endocrinol & Metab, Shenzhen, Guangdong, Peoples R China

[6] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou, Guangdong, Peoples R China

[7] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD USA

[8] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Anesthesiol, Nanchang, Jiangxi, Peoples R China

[9] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Endocrinol, Shenzhen, Guangdong, Peoples R China

[10] Fujian Normal Univ, Sch Phys Educ & Sport Sci, Fuzhou, Peoples R China

[11] Univ Hong Kong, Sch Biol Sci, Food & Nutr Sci, Hong Kong, Peoples R China

来源：

JACC-ADVANCES | 2025年 / 4卷 / 01期

关键词：

cardiovascular diseases; death; global burden of disease; ischemic heart disease; disability-adjusted life years; incidence; prevalence; RISK-FACTORS; YOUNG-ADULTS; CARDIOVASCULAR-DISEASES; UNITED-STATES;

D O I：

10.1016/j.jacadv.2024.101466

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Early-onset ischemic heart disease (IHD) is a growing burden associated with high disability and death. OBJECTIVES This study aimed to estimate the burden of incidence, prevalence, and disability-adjusted life years (DALY) of early-onset IHD from 1990 to 2019. METHODS Data on the burden of early-onset IHD (men<55 years, women<65 years), including prevalence, incidence, DALY, and deaths, were collected from the Global Burden of Disease study for 204 countries and territories from 1990 to 2019. RESULTS In 2019, early-onset IHD affected 5.34 million (95% uncertainty interval [UI]: 3.96-6.96) individuals globally. This resulted in 58.48 million (95% UI: 52.65-64.69) DALY and 1.44 million (95% UI: 1.29-1.59) deaths. Countries with a middle sociodemographic index (SDI) had the highest incidence cases (1.79 million, 95% UI: 1.32-2.34) and the low-middle SDI countries had the highest age-standardized incidence rate of 179.34 per 100,000 (95% UI: 134.38-231.94). Low-middle SDI countries exhibited the highest age-standardized death rate (57.13 per 100,000, 95% UI: 48.45-66.53) and age-standardized DALY rate (2,309.67 per 100,000, 95% UI: 1962.31-2,693.93). Globally, female incidence cases (2.77 million, 95% UI: 2.04-3.64) surpassed male (2.57 million, 95% UI: 1.92-3.32). The top 2 attributable risk factors were high low-density lipoprotein cholesterol and high systolic blood pressure. CONCLUSIONS The global incidence rate of early-onset IHD decreased from 1990 to 2019. The incidence rate was highest in low-middle SDI countries, and the burden of DALY was highest in low-middle SDI countries. The DALY and death rate were higher in men. High low-density lipoprotein cholesterol and high systolic blood pressure were the primary attributors. (JACC Adv. 2025;4:101466) (c) 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/).

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