Adult rhabdomyoma Rare differential diagnosis in frozen section examination

We report on a 73-year-old patient with formerly diagnosed melanoma and newly recognized tumor formation within the larynx. In a frozen section specimen, there was no indication of malignancy. Differential diagnosis favored a granular cell tumor at first. Immunohistochemistry and histomorphology after tissue transfer into paraffin led to the diagnosis of adult rhabdomyoma. This case report examines the histomorphologic and immunhistochemic differential diagnosis of large-cell laryngeal lesions with special focus on the challenges associated with frozen section specimens.