The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases

被引：0

作者：

Wolska, Waleria ^{[1
,2
]}

Gutowska, Izabela ^{[1
]}

Wszolek, Agata ^{[3
]}

Zwierello, Wojciech ^{[1
]}

机构：

[1] Pomeranian Med Univ, Dept Med Chem, Powstancow Wlkp 72, PL-70111 Szczecin, Poland

[2] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Erling Skjalgssons Gate 1, N-7491 Trondheim, Norway

[3] Univ Szczecin, Inst Biol, Waska 13, PL-71415 Szczecin, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 10期

关键词：

autophagy; cancer; diets; calorie restriction; intermittent fasting; CHAPERONE-MEDIATED AUTOPHAGY; DOWN-REGULATION; CELL-SURVIVAL; TUMOR-GROWTH; PROMOTES; RESTRICTION; METABOLISM; MECHANISMS; DIET; SUPPRESSION;

D O I：

10.3390/ijms26104742

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intermittent fasting (IF) is a dietary approach that influences key metabolic pathways, including autophagy-a crucial mechanism in maintaining cellular homeostasis. Autophagy plays a dual role in oncogenesis, acting both as a tumor suppressor and a survival mechanism under metabolic stress. IF has shown potential for reducing cancer risk and enhancing therapeutic efficacy by sensitizing tumor cells to chemotherapy and radiotherapy. However, its effects depend heavily on the type and stage of cancer. Potential risks, such as excessive weight loss and malnutrition, require careful evaluation. Further clinical studies are needed to optimize IF protocols as adjuncts to cancer therapy. This review discusses autophagy mechanisms induced by IF, their therapeutic implications in oncology, and the limitations of this dietary strategy.

引用

页数：18

共 126 条

[1] Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting [J].

Aksungar, Fehime B. ;

Topkaya, Aynur E. ;

Akyildiz, Mahmut .

ANNALS OF NUTRITION AND METABOLISM, 2007, 51 (01) :88-95

[2] Short-term fasting induces profound neuronal autophagy [J].

Alirezaei, Mehrdad ;

Kemball, Christopher C. ;

Flynn, Claudia T. ;

Wood, Malcolm R. ;

Whitton, J. Lindsay ;

Kiosses, William B. .

AUTOPHAGY, 2010, 6 (06) :702-710

[3] Targeting Autophagy in Cancer: Recent Advances and Future Directions [J].

Amaravadi, Ravi K. ;

Kimmelman, Alec C. ;

Debnath, Jayanta .

CANCER DISCOVERY, 2019, 9 (09) :1167-1181

[4] Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake [J].

Anson, RM ;

Guo, ZH ;

de Cabo, R ;

Iyun, T ;

Rios, M ;

Hagepanos, A ;

Ingram, DK ;

Lane, MA ;

Mattson, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :6216-6220

[5] Autophagy and intermittent fasting: the connection for cancer therapy? [J].

Antunes, Fernanda ;

Erustes, Adolfo Garcia ;

Costa, Angelica Jardim ;

Nascimento, Ana Carolina ;

Bincoletto, Claudia ;

Ureshino, Rodrigo Portes ;

Silva Pereira, Gustavo Jose ;

Smaili, Soraya Soubhi .

CLINICS, 2018, 73

[6] Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression (vol 105, pg 975, 2020) [J].

Bai, Bing ;

Wang, Xusheng ;

Li, Yuxin ;

Chen, Ping-Chung ;

Yu, Kaiwen ;

Dey, Kaushik Kumar ;

Yarbro, Jay M. ;

Han, Xian ;

Lutz, Brianna M. ;

Rao, Shuquan ;

Jiao, Yun ;

Sifford, Jeffrey M. ;

Han, Jonghee ;

Wang, Minghui ;

Tan, Haiyan ;

Shaw, Timothy I. ;

Cho, Ji-Hoon ;

Zhou, Suiping ;

Wang, Hong ;

Niu, Mingming ;

Mancieri, Ariana ;

Messler, Kaitlynn A. ;

Sun, Xiaojun ;

Wu, Zhiping ;

Pagala, Vishwajeeth ;

High, Anthony A. ;

Bi, Wenjian ;

Zhang, Hui ;

Chi, Hongbo ;

Haroutunian, Vahram ;

Zhang, Bin ;

Beach, Thomas G. ;

Yu, Gang ;

Peng, Junmin .

NEURON, 2020, 106 (04) :700-700

[7] Cancer-associated cachexia [J].

Baracos, Vickie E. ;

Martin, Lisa ;

Korc, Murray ;

Guttridge, Denis C. ;

Fearon, Kenneth C. H. .

NATURE REVIEWS DISEASE PRIMERS, 2018, 4

[8] Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats [J].

Belkacemi, Louiza ;

Selselet-Attou, Ghalem ;

Hupkens, Emeline ;

Nguidjoe, Evrard ;

Louchami, Karim ;

Sener, Abdullah ;

Malaisse, Willy J. .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2012, 2012

[9] Rapamycin passes the torch: a new generation of mTOR inhibitors [J].

Benjamin, Don ;

Colombi, Marco ;

Moroni, Christoph ;

Hall, Michael N. .

NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (11) :868-880

[10] Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models [J].

Bianchi, Giovanna ;

Martella, Roberto ;

Ravera, Silvia ;

Marini, Cecilia ;

Capitanio, Selene ;

Orengo, Annamaria ;

Emionite, Laura ;

Lavarello, Chiara ;

Amaro, Adriana ;

Petretto, Andrea ;

Pfeffer, Ulrich ;

Sambuceti, Gianmario ;

Pistoia, Vito ;

Raffaghello, Lizzia ;

Longo, Valter D. .

ONCOTARGET, 2015, 6 (14) :11806-11819

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