BackgroundThis study aimed to identify groups of risk perception of illicit drug consumption and associated sociodemographic and mental health factors in Singapore.MethodsA representative sample of 6,509 Singapore citizens and permanent residents aged 15 to 65 years was randomly selected for participation over 14 months. Information on perceived risk related to illicit drug consumption, and correlates were collected via questionnaires. Data were analysed using latent class analysis to identify risk perception profiles. Logistic regression analyses were performed to determine the sociodemographic and mental health correlates across different risk perception profiles.ResultsFour profiles emerged; high risk perception across all substances and frequencies, low risk perception across all substances and frequencies, low risk perception of cannabis, and low risk perception of occasional illicit drug consumption. About 9.4% (n = 557) reported low risk perception of cannabis. Males (vs. females, RR: 2.15, 95% CI: 1.57-2.94) were more likely to have a low risk perception of cannabis. Those aged 35-65 years (35-49 vs. 15-34, RR: 0.37, 95% CI: 0.25-0.54; 50-65 vs. 15-34, RR: 0.19, 95% CI: 0.10-0.37), with secondary school (vs. degree and above, RR: 0.23, 95% CI: 0.13-0.39) or pre-tertiary (vs. degree and above, RR: 0.42, 95% CI: 0.29-0.61) education were less likely to have a low risk perception of cannabis. Ever-smokers (vs. non-smokers, RR: 1.86, 95% CI: 1.31-2.64), and those grouped as "safe drinking" (vs. abstainers, RR: 3.80, 95% CI: 2.50-5.77) or "hazardous drinking" (vs. abstainers, RR: 7.00, 95% CI: 3.69-13.28) were more likely to perceive low risk of cannabis. Individuals with a low risk perception across all substances and profiles were more likely to report symptoms of anxiety (OR: 7.17, 95% CI: 1.31-38.98) when compared to high risk perception across all substances and frequencies individuals.ConclusionsThese findings provide critical insights for tailoring prevention and education initiatives to address substance use behaviours in Singapore.