Pd/C-Catalyzed Dehydrogenative [3+2] Cycloaddition for the Synthesis of Dihydropyrrolo[2,1-a]isoquinolines

被引：0

作者：

Li, You-Gui ^{[1
]}

Lu, Ji-Chao ^{[2
]}

Wang, Meng-Cheng ^{[2
]}

Wu, Bo ^{[1
]}

She, Shi-Ke ^{[3
]}

Wu, Xiang ^{[2
]}

机构：

[1] Wuyi Univ, Sch Environm & Chem Engn, Jiangmen 529020, Peoples R China

[2] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Value Added Catalyt Convers & R, Hefei 230009, Peoples R China

[3] China Tobacco Anhui Ind Co Ltd, Res & Dev Ctr, Hefei 230088, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 23期

关键词：

TERTIARY-AMINES; AROMATIZATION; PALLADIUM; CASCADE;

D O I：

10.1021/acs.joc.5c00904

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd/C-catalyzed dehydrogenative [3 + 2] cycloaddition/oxidative aromatization cascade process for the synthesis of dihydropyrrolo[2,1-a] isoquinolines has been developed. Pd/C was employed as a reusable catalyst, enabling good yields of the desired products without the requirement for additional oxidants. Remarkably, after five cycles, the palladium catalyst preserved its catalytic efficiency. Moreover, this approach offers a succinct total synthesis of lamellarin G trimethyl ether.

引用

页码：7995 / 7999

页数：5

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