Pragmatic Clinical Trials in Neurology

被引：0

作者：

Qureshi, Adnan I. ^{[1
]}

Bartlett-Esquilant, Gillian ^{[2
]}

Brown, Alexandra ^{[3
]}

McClay, James ^{[2
]}

Pasnoor, Mamatha ^{[4
]}

Barohn, Richard J. ^{[5
]}

机构：

[1] Univ Missouri, Dept Neurol, Columbia, MO 65212 USA

[2] Texas A&M, Dept Primary Care & Rural Med, Coll Med, College Stn, TX USA

[3] Univ Kansas, Med Ctr, Dept Biostat & Data Sci, Kansas City, KS USA

[4] Univ Kansas, Sch Med, Dept Neurol, Kansas City, KS USA

[5] Univ Missouri, Off Execut Vice Chancellor Hlth Affairs, Columbia, MO USA

来源：

ANNALS OF NEUROLOGY | 2025年 / 97卷 / 06期

关键词：

REMITTING MULTIPLE-SCLEROSIS; CLUSTER-RANDOMIZED-TRIALS; TRANSIENT ISCHEMIC ATTACK; GUILLAIN-BARRE-SYNDROME; ACUTE STROKE; OPEN-LABEL; SWALLOWING DYSFUNCTION; CAROTID-ENDARTERECTOMY; GLATIRAMER ACETATE; INFORMED-CONSENT;

D O I：

10.1002/ana.27244

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The need for pragmatic clinical trials evaluating therapeutic interventions in patients with neurological disease is continually increasing due to availability of multiple therapeutic interventions (comparative effectiveness), multifaceted approaches (multiple concurrent synergistic therapeutic interventions), and gaps in trial-specific and real-world population outcomes. Several designs for pragmatic trials are available, including individual randomized trials with pragmatic characteristics, cluster-randomized and non-randomized trials, and observational prospective cohort studies. Cluster trials may have parallel cluster and crossover (unidirectional, bidirectional, and alternating crossover) designs. There are unique aspects of consenting and data collection leveraging existing registries, electronic health records (EHRs), and claims data that make pragmatic trials most suited to study the effectiveness of therapeutic interventions in patients with neurological diseases in real-world settings. ANN NEUROL 2025

引用

页码：1022 / 1037

页数：16

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