Pd-Catalyzed Ring-Opening Defluorinative Arylation of gem-Difluorocyclopropanes with Arylsilanes

被引：0

作者：

Liu, Haidong ^{[1
]}

Li, Lin ^{[1
]}

Qian, Yupeng ^{[1
]}

Li, Siyuan ^{[1
]}

Jia, Xinjian ^{[1
]}

Luo, Haiqing ^{[1
]}

机构：

[1] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Jiangxi, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2025年

基金：

中国国家自然科学基金;

关键词：

arylation; arylsilanes; C-C bond insertion; difluorocyclopropanes; Pd-catalyzed; CROSS-COUPLING REACTION; C-H ARYLATION; BUILDING-BLOCKS; DIFLUORINATED CYCLOPROPANES; ARYL SILANES; PALLADIUM; FLUORINE; CONSTRUCTION; ALLYLATION; ACTIVATION;

D O I：

10.1002/adsc.202500298

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, a Pd-catalyzed ring-opening defluorinative arylation of gem-difluorocyclopropanes with arylsilanes is presented, employing ethanol (EtOH) as a sustainable solvent. This methods enables a straightforward strategy for constructing monofluoro-substituted alkenes using gem-difluorocyclopropanes as fluorine-containing building blocks. In this reaction, environmentally friendly arylsilanes serve as the aryl sources, with Et3N center dot 3HF acting as the activator for the C-Si bond cleavage. This silicon-based protocol demonstrates broad substrate scope and good stereoselectivity, yielding mainly Z-configured products (Z/E >= 13:1).

引用

页数：6

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