Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies

被引：4
作者：
Haddadin, Laurence [1 ]
Sun, Xueqin [1 ]
机构：
[1] Sanford Burnham Prebys Med Discovery Inst, NCI Designated Canc Ctr, Canc Genome & Epigenet Program, La Jolla, CA 92037 USA
来源：
CELLS | 2025年 / 14卷 / 07期
基金：
美国国家卫生研究院;
关键词：
cancer; stem cells; signaling pathways; genetics; epigenetics; tumor microenvironment; epithelial-mesenchymal transition (EMT); extracellular matrix (ECM); tumor heterogeneity; metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; HEDGEHOG SIGNALING PATHWAY; GAMMA-SECRETASE INHIBITORS; HYPOXIA-INDUCIBLE FACTORS; DNA-DAMAGE RESPONSE; BREAST-CANCER; PHASE-I; TUMOR SUPPRESSION; PIK3CA MUTATIONS; DOSE-ESCALATION;
D O I：
10.3390/cells14070538
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stem cells have emerged as a pivotal area of research in the field of oncology, offering new insights into the mechanisms of cancer initiation, progression, and resistance to therapy. This review provides a comprehensive overview of the role of stem cells in cancer, focusing on cancer stem cells (CSCs), their characteristics, and their implications for cancer therapy. We discuss the origin and identification of CSCs, their role in tumorigenesis, metastasis, and drug resistance, and the potential therapeutic strategies targeting CSCs. Additionally, we explore the use of normal stem cells in cancer therapy, focusing on their role in tissue regeneration and their use as delivery vehicles for anticancer agents. Finally, we highlight the challenges and future directions in stem cell research in cancer.
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页数：40
相关论文
共 341 条
[1]   DNA damage response and resistance of cancer stem cells [J].
Abad, Etna ;
Graifer, Dmitry ;
Lyakhovich, Alex .
CANCER LETTERS, 2020, 474 :106-117
[2]   Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson's disease could soon be here [J].
Abbott, Alison .
NATURE, 2025, 637 (8044) :18-20
[3]   RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives [J].
Alawieh, Dana ;
Cysique-Foinlan, Leila ;
Willekens, Christophe ;
Renneville, Aline .
BLOOD CANCER JOURNAL, 2024, 14 (01)
[4]   Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells [J].
Alhabbab, Rowa Y. .
FRONTIERS IN GENETICS, 2020, 11
[5]   Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets [J].
Alvarez-Teijeiro, Saul ;
Garcia-Inclan, Cristina ;
Angeles Villaronga, M. ;
Casado, Pedro ;
Hermida-Prado, Francisco ;
Granda-Diaz, Rocio ;
Rodrigo, Juan P. ;
Calvo, Fernando ;
del-Rio-Ibisate, Nagore ;
Gandarillas, Alberto ;
Moris, Francisco ;
Hermsen, Mario ;
Cutillas, Pedro ;
Garcia-Pedrero, Juana M. .
CANCERS, 2018, 10 (09)
[6]   Cancer Stem Cells (CSCs), Circulating Tumor Cells (CTCs) and Their Interplay with Cancer Associated Fibroblasts (CAFs): A New World of Targets and Treatments [J].
Aramini, Beatrice ;
Masciale, Valentina ;
Arienti, Chiara ;
Dominici, Massimo ;
Stella, Franco ;
Martinelli, Giovanni ;
Fabbri, Francesco .
CANCERS, 2022, 14 (10)
[7]   Epithelial stem cells, wound healing and cancer [J].
Arwert, Esther N. ;
Hoste, Esther ;
Watt, Fiona M. .
NATURE REVIEWS CANCER, 2012, 12 (03) :170-180
[8]   EpCAM (CD326) finding its role in cancer [J].
Baeuerle, P. A. ;
Gires, O. .
BRITISH JOURNAL OF CANCER, 2007, 96 (03) :417-423
[9]   CHD5 is a tumor suppressor at human 1p36 [J].
Bagchi, Anindya ;
Papazoglu, Cristian ;
Wu, Ying ;
Capurso, Daniel ;
Brodt, Michael ;
Francis, Dailia ;
Bredel, Markus ;
Vogel, Hannes ;
Mills, Alea A. .
CELL, 2007, 128 (03) :459-475
[10]   Sphere-Formation Assay: Three-Dimensional in vitro Culturing of Prostate Cancer Stem/Progenitor Sphere-Forming Cells [J].
Bahmad, Hisham F. ;
Cheaito, Katia ;
Chalhoub, Reda M. ;
Hadadeh, Ola ;
Monzer, Alissar ;
Ballout, Farah ;
El-Hajj, Albert ;
Mukherji, Deborah ;
Liu, Yen-Nien ;
Daoud, Georges ;
Abou-Kheir, Wassim .
FRONTIERS IN ONCOLOGY, 2018, 8
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