Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

被引：0

作者：

Fujimoto, Takuya ^{[1
]}

Andoh, Tooru ^{[2
]}

Sudo, Tamotsu ^{[3
]}

Sakuma, Toshiko ^{[4
]}

Fujita, Ikuo ^{[1
]}

Sakurai, Yoshinori ^{[5
]}

Takata, Takushi ^{[5
]}

Tanaka, Hiroki ^{[5
]}

Kawamoto, Teruya ^{[6
]}

Yahiro, Shunsuke ^{[1
]}

Hara, Hitomi ^{[7
]}

Fukase, Naomasa ^{[7
]}

Akisue, Toshihiro ^{[7
,8
]}

Ichikawa, Hideki ^{[2
]}

Kuroda, Ryosuke ^{[7
]}

Suzuki, Minoru ^{[5
]}

机构：

[1] Hyogo Canc Ctr, Dept Orthopaed Surg, 13-70 Kitaouji Cho, Akashi 6738558, Japan

[2] Kobe Gakuin Univ, Fac Pharmaceut Sci, Kobe 6508586, Japan

[3] Fujita Hlth Univ, Dept Genom Med, Toyoake 4701192, Japan

[4] Saiseikai Hyogoken Hosp, Dept Diagnost Pathol, Kobe 6511302, Japan

[5] Kyoto Univ, Inst Integrated Radiat & Nucl Sci, Kyoto 5900494, Japan

[6] Konan Med Ctr, Dept Orthopaed Surg, Kobe 6580064, Japan

[7] Kobe Univ, Grad Sch Med, Dept Orthopaed Surg, Kobe 6500017, Japan

[8] Kobe Univ, Grad Sch Hlth Sci, Dept Rehabil Sci, Kobe 6540142, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 2025年 / 222卷

关键词：

p-borono-L-phenylalanine (L-BPA); Boron neutron capture therapy (BNCT); Epithelioid sarcoma; VA-ES-BJ; Cell line; BORONOPHENYLALANINE; MELANOMA;

D O I：

10.1016/j.apradiso.2025.111846

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were destroyed. This study suggests the potential of BNCT as a new option for the treatment of human ES.

引用

页数：7

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