Remote Symptom Monitoring of Patients With Advanced Lung Cancer (The ProWide Study): A Randomized Controlled Trial

被引：0

作者：

Friis, Rasmus Blechingberg ^{[1
]}

Pappot, Helle ^{[2
,3
]}

Hjollund, Niels Henrik ^{[4
,5
]}

McCulloch, Tine ^{[6
]}

Holt, Marianne Ingerslev ^{[7
]}

Persson, Gitte Fredberg ^{[3
,8
]}

Wedervang, Kim ^{[9
]}

Clausen, Malene Martini ^{[2
,10
]}

Wahlstrom, Stine ^{[11
]}

Hansen, Karin Holmskov ^{[12
]}

Rasmussen, Torben Riis ^{[13
]}

Dalton, Susanne Oksbjerg ^{[14
,15
]}

Jakobsen, Erik ^{[16
]}

Linnet, Hanne ^{[1
]}

Skuladottir, Halla ^{[1
]}

Danish Lung Canc Grp

机构：

[1] Godstrup Hosp, Dept Oncol, Herning, Denmark

[2] Rigshosp, Copenhagen Univ Hosp, Dept Oncol, Copenhagen, Denmark

[3] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[4] Godstrup Hosp, AmbuFlex Ctr Patient Reported Outcomes, Herning, Denmark

[5] Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark

[6] Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark

[7] Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark

[8] Copenhagen Univ Hosp Herlev & Gentofte, Dept Oncol, Herlev, Denmark

[9] Hosp Soenderjylland, Dept Oncol, Sonderborg, Denmark

[10] Rigshosp, Copenhagen Univ Hosp, Dept Nucl Med Clin Physiol & PET & Cluster Mol Ima, Copenhagen, Denmark

[11] North Zealand Hosp, Dept Oncol, Hillerod, Denmark

[12] Odense Univ Hosp, Dept Oncol, Odense, Denmark

[13] Aarhus Univ Hosp, Dept Resp Dis, Aarhus, Denmark

[14] Danish Canc Soc, Danish Canc Inst, Copenhagen, Denmark

[15] Zealand Univ Hosp, Dept Clin Oncol & Palliat Care, Naestved, Denmark

[16] Odense Univ Hosp, Dept Cardiac Thorac & Vasc Surg, Odense, Denmark

来源：

JCO ONCOLOGY PRACTICE | 2025年 / 21卷 / 06期

关键词：

QUALITY-OF-LIFE; REPORTED OUTCOMES; PALLIATIVE CARE; INTERNET; QLQ-C30;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSERemote symptom monitoring of patients with cancer has previously shown potential for improving clinical outcomes. This study aimed to evaluate the effects of remote symptom monitoring in patients with lung cancer after palliative induction treatment.METHODSIn a Danish multicenter randomized controlled trial, patients were randomly assigned 1:1 to remote symptom monitoring (intervention arm) added to standard of care versus standard of care (control arm). Key eligibility criteria were stage III-IV lung cancer (small cell lung cancer and non-small cell lung cancer), Eastern Cooperative Oncology Group performance status <= 2, and no sign of disease progression after initial induction treatment. Patients in the intervention arm completed a weekly electronic questionnaire, assessing 14 common symptoms related to lung cancer. When a patient reported a severity exceeding a predefined threshold, the patient was subsequently contacted by phone to address potential clinical needs. Symptom monitoring was discontinued after progression. The primary outcome was overall survival (OS). Secondary measures included assessment of health-related quality of life (HRQoL).RESULTSOf 494 randomly assigned patients, 240 were assigned to the intervention arm and 254 were assigned to the control arm. At a median follow-up of 3.5 years, symptom monitoring did not significantly improve OS compared with standard care (hazard ratio [HR], 0.93 [95% CI, 0.75 to 1.16]; P = .53). Exploratory subgroup analyses indicated improved survival for patients treated with carboplatin/vinorelbine (HR, 0.67 [95% CI, 0.45 to 0.98]; P = .04) and in departments with previous implementation of patient-reported outcomes (HR, 0.66 [95% CI, 0.44 to 0.98]; P = .04). HRQoL analyses did not reveal clinically meaningful effects.CONCLUSIONIn the Danish health care system, remote symptom monitoring did not improve OS but led to modest improvements in HRQoL for patients with advanced lung cancer.

引用

页数：14

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