Digestive characteristics of Tibetan tea polyphenols and polysaccharides in vitro and their effects on gut microbiota

被引：0

作者：

Zeng, Zhen ^{[1
]}

Jiang, Chunping ^{[1
]}

Deng, Fengshi ^{[1
]}

Zhang, Lijia ^{[1
]}

Zhang, Qiyun ^{[1
]}

Fang, Zhengfeng ^{[1
]}

Hu, Bin ^{[1
]}

Chen, Hong ^{[1
]}

Wang, Caixia ^{[1
]}

Wu, Wenjuan ^{[2
]}

Liu, Yuntao ^{[1
]}

机构：

[1] Sichuan Agr Univ, Coll Food Sci, 46 Xinkang Rd, Yaan 625014, Sichuan, Peoples R China

[2] Sichuan Agr Univ, Coll Sci, Yaan 625014, Peoples R China

来源：

FOOD CHEMISTRY | 2025年 / 483卷

关键词：

Tibetan tea; Polyphenols; Polysaccharides; Digestion; Gut microbiota; STABILITY; FERMENTATION;

D O I：

10.1016/j.foodchem.2025.144289

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Tibetan tea contains highly valuable bioactive components like polyphenols and polysaccharides, which can regulate gut microbiota and promote bodily health. This study systematically investigated the gastrointestinal digestion and colonic fermentation behavior of Tibetan tea polyphenols (TPP), polysaccharides (TPS), and their polyphenol-polysaccharide complex (TC). TPP, TPS, and TC demonstrated minimal changes in physicochemical and structural characteristics after gastrointestinal digestion. Following 24 h of fecal fermentation, all components significantly degraded and altered microbial composition (pH decreased to 6.44, 5.76, and 6.14, respectively), promoting dominant flora such as Phascolarctobacterium and Lachnoclostridium. Differentially, TPS and TC demonstrated stronger promotion of dominant Bifidobacterium, Faecalibacterium, and Collinsella, whereas TPP preferentially enriched Megasphaera and Butyricicoccus. Additionally, fermentation markedly increased the concentration of short-chain fatty acids (SCFAs), with TPS yielding the highest total SCFAs (17.29 +/- 0.50 mM), particularly acetic and propionic acids. Overall, Tibetan tea polyphenols and polysaccharides may serve as potential prebiotics to improve intestinal health.

引用

页数：11

共 44 条

[1] Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals [J].

Asnicar, Francesco ;

Berry, Sarah E. ;

Valdes, Ana M. ;

Nguyen, Long H. ;

Piccinno, Gianmarco ;

Drew, David A. ;

Leeming, Emily ;

Gibson, Rachel ;

Le Roy, Caroline ;

Al Khatib, Haya ;

Francis, Lucy ;

Mazidi, Mohsen ;

Mompeo, Olatz ;

Valles-Colomer, Mireia ;

Tett, Adrian ;

Beghini, Francesco ;

Dubois, Leonard ;

Bazzani, Davide ;

Thomas, Andrew Maltez ;

Mirzayi, Chloe ;

Khleborodova, Asya ;

Oh, Sehyun ;

Hine, Rachel ;

Bonnett, Christopher ;

Capdevila, Joan ;

Danzanvilliers, Serge ;

Giordano, Francesca ;

Geistlinger, Ludwig ;

Waldron, Levi ;

Davies, Richard ;

Hadjigeorgiou, George ;

Wolf, Jonathan ;

Ordovas, Jose M. ;

Gardner, Christopher ;

Franks, Paul W. ;

Chan, Andrew T. ;

Huttenhower, Curtis ;

Spector, Tim D. ;

Segata, Nicola .

NATURE MEDICINE, 2021, 27 (02) :321-+

[2] Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease [J].

Bowerman, Kate L. ;

Rehman, Saima Firdous ;

Vaughan, Annalicia ;

Lachner, Nancy ;

Budden, Kurtis F. ;

Kim, Richard Y. ;

Wood, David L. A. ;

Gellatly, Shaan L. ;

Shukla, Shakti D. ;

Wood, Lisa G. ;

Yang, Ian A. ;

Wark, Peter A. ;

Hugenholtz, Philip ;

Hansbro, Philip M. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[3] INFOGEST static in vitro simulation of gastrointestinal food digestion [J].

Brodkorb, Andre ;

Egger, Lotti ;

Alminger, Marie ;

Alvito, Paula ;

Assuncao, Ricardo ;

Ballance, Simon ;

Bohn, Torsten ;

Bourlieu-Lacanal, Claire ;

Boutrou, Rachel ;

Carriere, Frederic ;

Clemente, Alfonso ;

Corredig, Milena ;

Dupont, Didier ;

Dufour, Claire ;

Edwards, Cathrina ;

Golding, Matt ;

Karakaya, Sibel ;

Kirkhus, Bente ;

Le Feunteun, Steven ;

Lesmes, Uri ;

Macierzanka, Adam ;

Mackie, Alan R. ;

Martins, Carla ;

Marze, Sebastien ;

McClements, David Julian ;

Menard, Olivia ;

Minekus, Mans ;

Portmann, Reto ;

Santos, Claudia N. ;

Souchon, Isabelle ;

Singh, R. Paul ;

Vegarud, Gerd E. ;

Wickham, Martin S. J. ;

Weitschies, Werner ;

Recio, Isidra .

NATURE PROTOCOLS, 2019, 14 (04) :991-1014

[4] Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy [J].

Das, Taraprasad ;

Jayasudha, Rajagopalaboopathi ;

Chakravarthy, SamaKalyana ;

Prashanthi, Gumpili Sai ;

Bhargava, Archana ;

Tyagi, Mudit ;

Rani, Padmaja Kumari ;

Pappuru, Rajeev Reddy ;

Sharma, Savitri ;

Shivaji, Sisinthy .

SCIENTIFIC REPORTS, 2021, 11 (01)

[5] Gut microbiome and health: mechanistic insights [J].

de Vos, Willem M. ;

Tilg, Herbert ;

Van Hul, Matthias ;

Cani, Patrice D. .

GUT, 2022, 71 (05) :1020-1032

[6] Structural characteristics and immunomodulatory effects of polysaccharides extracted from plant seeds: A review [J].

Dong, Xiaodan ;

Deng, Peng ;

Wang, Xinkun ;

Peng, Chune ;

Peng, Lizeng .

TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2024, 153

[7] Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health [J].

Fassarella, Marina ;

Blaak, Ellen E. ;

Penders, John ;

Nauta, Arjen ;

Smidt, Hauke ;

Zoetendal, Erwin G. .

GUT, 2021, 70 (03) :595-605

[8] Simulated digestion and in vitro fermentation of a polysaccharide from lotus (Nelumbo nucifera Gaertn.) root residue by the human gut microbiota [J].

Guan, Xueting ;

Feng, Yujing ;

Jiang, Yunyao ;

Hu, Yeye ;

Zhang, Ji ;

Li, Zhengpeng ;

Song, Chao ;

Li, Fu ;

Hou, Jincai ;

Shen, Ting ;

Hu, Weicheng .

FOOD RESEARCH INTERNATIONAL, 2022, 155

[9]

Hazan S., 2022, BMJ open gastroenterology, V9, DOI 10.

[10] Insight into Tea Flavonoids: Composition and Chemistry [J].

He, Hua-Feng ;

Wei, Kang ;

Yin, Junfeng ;

Ye, Yang .

FOOD REVIEWS INTERNATIONAL, 2021, 37 (08) :812-823

← 1 2 3 4 5 →