Synthesis and characterization of a heterobimetallic [FeIIMnII] cyanide-bridged coordination polymer and its in vitro antitumor activity

A novel Fe-Mn cyanide-bridged compound 1, {[Fe-2(II)(bpy)(4)(mu-CN)(4)Mn-II(DMF)(2)](PF6)(2)center dot H2O}n, was achieved by reaction of cis-Fe-II(bpy)(2)(CN)(2)center dot 3H(2)O with Mn-II(OAc)center dot 4H(2)O in a DMF solution in the presence of ammonium hexafluorophosphate. Compound 1 was characterized by IR, electronic absorption spectra and elemental analysis, and X-ray Crystallography. Compound 1 crystallizes in the monoclinic system, space group C2/c. The crystal structure of compound 1 contains two mononuclear cis-Fe-II(bpy)(2)(CN)(2) neutral molecule, one [Mn-II(DMF)2](2+) cation, two uncoordinated PF6- anions and one uncoordinated water molecule. Each Fe-II(bpy)(2)(CN)(2) unit is connected to two [Mn-II(DMF)(2)](2+) cations via CN groups in cis-conformation, and each [MnII(DMF)(2)](2+) cation is linked to four FeII(bpy)(2)(CN)(2) unit via CN groups. Each two FeII(bpy)(2)(CN)(2) units bridge two Mn2+ ions through cyanido bridges in the cis- positions linked alternately to form a 12-membered ring molecular square. The two cis positions remaining on each manganese continue to be alternately connected by two cyanide groups from another iron unit, and such alternation forms a 2-dimensional structure. The in vitro activity of compound 1 was evaluated in A549 and HeLa as well as MCF7 cell lines.