The role of myocardial fibrosis in the diabetic cardiomyopathy

被引：0
作者：
Sun, Jinghui [1 ]
Zhou, Ruiling [1 ]
Liu, Mi [1 ]
Zhang, Dawu [1 ]
机构：
[1] China Acad Chinese Med Sci, Xiyuan Hosp, Natl Clin Res Ctr Chinese Med Cardiol, Beijing 10091, Peoples R China
来源：
DIABETOLOGY & METABOLIC SYNDROME | 2025年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Diabetic cardiomyopathy; Myocardial fibrosis; Heart failure; Diabetes mellitus; Cardiovascular complication; NF-KAPPA-B; TO-MESENCHYMAL TRANSITION; KINASE-C-BETA; EXTRACELLULAR-MATRIX PRODUCTION; ENDOTHELIAL PROGENITOR CELLS; DENDROBIUM-OFFICINALE-KIMURA; LEFT-VENTRICULAR HYPERTROPHY; ACTIVATED RECEPTOR-GAMMA; CHRONIC KIDNEY-DISEASE; NITRIC-OXIDE SYNTHASE;
D O I：
10.1186/s13098-025-01783-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic cardiomyopathy (DCM), a main cardiovascular complication of diabetes mellitus, can eventually develop into heart failure and seriously affect the prognosis of diabetic patients. Myocardial fibrosis (MF) is the main factor causing ventricular wall stiffness and heart failure in DCM. Early control of MF in DCM is of great significance to prevent or postpone the progression of DCM to heart failure. In this review, we systematically analyzed the relevant studies on diabetic MF in recent years, explored the formation mechanism of MF in the pathological process of DCM, and summarized and analyzed in detail the current studies with antifibrotic treatment for DCM, so as to provide guidance for the development of prevention and treatment strategies for MF in DCM.
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页数：24
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