Palladium-Catalyzed Ring-Opening Defluorinative Hiyama Cross-Coupling of gem-Difluorocyclopropanes with Arylsilanes

被引：0
作者：
Wang, Zhi-Shang [1 ]
Hong, Dong-Guo [1 ]
Li, Hongfang [1 ]
Loh, Teck-Peng [1 ,3 ]
Lu, Ming-Zhu [1 ,2 ]
机构：
[1] Henan Univ Technol, Coll Adv Interdisciplinary Sci & Technol, Zhengzhou 450001, Peoples R China
[2] Huaiyin Normal Univ, Sch Chem & Chem Engn, Huain 223300, Peoples R China
[3] Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol, Singapore 637371, Singapore
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 17期
基金：
中国国家自然科学基金;
关键词：
C-H ARYLATION; DIFLUORINATED CYCLOPROPANES; FLUORINE; ACTIVATION; INDOLES; ACCESS; ALKENYLATION; ARENES; ARYL;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report an efficient palladium-catalyzed ring-opening defluorinative Hiyama cross-coupling of gem-difluorocyclopropanes with structurally diverse (hetero)arylsilanes through C-C bond activation and C-F bond cleavage. This regioselective ring-opening defluorinative Hiyama cross-coupling features a broad substrate scope with excellent functional group compatibility, affording a diverse variety of linear 2-fluoroallylic scaffolds in good yields with high Z-selectivity.
引用
收藏
页码：6054 / 6062
页数：9
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