Synthesis of functionalized silicon quantum dots for biological detection and imaging

被引：0

作者：

Jain, Atishay ^{[1
]}

Fopase, Rushikesh ^{[1
]}

Sharma, Laipubam Gayatri ^{[1
]}

Panda, Chinmaya ^{[1
]}

Pandey, Lalit M. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Biointerface & Environm Engn Lab, Gauhati 781039, Assam, India

来源：

MATERIALS LETTERS | 2025年 / 394卷

关键词：

Silicon quantum dots; Photoluminescence; Fluorescence quenching; Hydrothermal method; Amino acids;

D O I：

10.1016/j.matlet.2025.138620

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Quantum dots are semiconductor nanomaterials with high luminescence and low photobleaching, making them ideal for long-term, multiplexed fluorescence imaging in biomedical research as an alternative to conventional fluorophores. The current study attempts to synthesize silicon QDs (SiQDs) using a hydrothermal method for their potential in biological applications. The prepared samples showed particle size in the range of 1.86 +/- 0.18 nm and a peak at 461 nm with blue color emission when excited with a long-wavelength UV source. The synthesized SiQDs exhibited excellent cytocompatibility against HEK-239 cells. The fluorescence quenching-based interaction with amino acids suggested the stable static nature of binding of SiQDs with proline, giving the binding constant (Ka) value of 4073. Such stable interactions confirmed the potential of prepared SiQDs in biosensing and bioimaging applications.

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