Halogen Bonding Promoted Photoinduced Synthesis of 3,3-Disubstituted Oxindoles

被引：0

作者：

Chen, Kun-Quan ^{[1
]}

Zhang, Jia ^{[2
]}

Chen, Xiao-Bo ^{[2
]}

Sun, De-Qun ^{[2
]}

机构：

[1] Putian Univ, Sch Pharm & Med Technol, Key Lab Med Microecol, Putian 351100, Peoples R China

[2] Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621010, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 18期

关键词：

FRIEDEL-CRAFTS ALKYLATION; CONSTRUCTION; FUNCTIONALIZATION; ACTIVATION; ARENES;

D O I：

10.1021/acs.joc.4c02963

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A photoinduced and catalyst-free radical cyclization process for the synthesis of 3,3-disubstituted oxindoles is reported. This method utilizes readily available alpha-bromoanilides as substrates, showcasing a broad substrate scope. The reaction mechanism is facilitated by a photoactivated charge transfer complex based on the halogen bonding of alpha-bromoanilide with TMG and alcohol.

引用

页码：6318 / 6322

页数：5

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