Associations of long-term exposure to fine particulate matter and its components with ovarian aging: Evidence from a cross-sectional study in China

被引：0

作者：

Cao, Zifeng ^{[1
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Wu, Xinyi ^{[1
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Liu, Hongyuan ^{[1
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Xu, Keyan ^{[1
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Yang, Yehuan ^{[8
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Yang, Manting ^{[1
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Wei, Daimin ^{[1
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Zhao, Shidou ^{[1
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Jiao, Xue ^{[1
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Zhao, Qi ^{[9
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Zheng, Ruimin ^{[8
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Qin, Yingying ^{[1
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Guo, Ting ^{[1
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Chen, Zi-Jiang ^{[1
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机构：

[1] Shandong Univ, Inst Women Children & Reprod Hlth, Ctr Reprod Med, State Key Lab Reprod Med & Offspring Hlth, Jinan 250012, Peoples R China

[2] Shandong Univ, Natl Res Ctr Assisted Reprod Technol & Reprod Gene, Jinan 250012, Shandong, Peoples R China

[3] Shandong Univ, Key Lab Reprod Endocrinol, Minist Educ, Jinan 250012, Shandong, Peoples R China

[4] Shandong Technol Innovat Ctr Reprod Hlth, Jinan 250012, Shandong, Peoples R China

[5] Shandong Prov Clin Res Ctr Reprod Hlth, Jinan 250012, Shandong, Peoples R China

[6] Shandong Key Lab Reprod Res & Birth Defect Prevent, Jinan 250012, Shandong, Peoples R China

[7] Chinese Acad Med Sci 2021RU001, Res Unit Gametogenesis & Hlth ART Offspring, Jinan 250012, Shandong, Peoples R China

[8] NHC, Natl Ctr Women & Childrens Hlth, 12 Dahuisi Rd, Beijing 100081, Peoples R China

[9] Shandong Univ, Cheeloo Coll Med, Sch Publ Hlth, Dept Epidemiol, Jinan 250012, Shandong, Peoples R China

[10] Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai, Peoples R China

[11] Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Reprod Med, Sch Med, Shanghai, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2025年 / 494卷

基金：

中国国家自然科学基金;

关键词：

Ovarian aging; Long-term exposure; PM2.5; components; Age at natural menopause; Early menopause; AIR-POLLUTION; NATURAL MENOPAUSE; BLACK CARBON; AGE; PM2.5; HEALTH; TRENDS; RISK; TIME;

D O I：

10.1016/j.jhazmat.2025.138589

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study aimed to investigate associations between long-term exposure to PM2.5, or its constituents, and ovarian aging, assessed by age at natural menopause (ANM) and early menopause (EM) prevalence. A total of 15,345 postmenopausal women were recruited from an epidemiologic survey conducted across 12 provinces in China (2023-2024). Concentrations of air pollutants [PM2.5 mass, sulfate (SO42-), nitrate (NO3- ), ammonium (NH4+), organic matter (OM), and black carbon (BC)] were obtained from the Tracking Air Pollution in China database. Multivariable regression models with random effects and quantile g-computation models were used to evaluate associations. Each interquartile range increase in 5-year average concentrations of PM2.5, SO42-, NO3- , NH4+, OM, or BC were correlated with significant changes of -0.79 (95 %CI: -0.87, -0.72), -0.98 (95 %CI: and -1.02 (95 %CI: -1.09, -0.96) in ANM, respectively. Joint exposure analysis revealed that the five combined PM2.5 constituents shared a negative association with ANM in which BC provided the largest weight. These pollutants were also significantly associated with elevated EM prevalence, wherein BC provided the strongest contribution. The associations were stronger in women with a history of smoking, other hazardous environmental exposure, and lower education level.

引用

页数：10

共 69 条

[21] The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis [J].