Advances in biosensors for diagnosis of Alzheimer's and Parkinson's diseases

被引：0

作者：

Negahdary, Masoud ^{[1
,2
]}

Sakthinathan, Indherjith ^{[3
]}

Mirsadoughi, Ensiyeh ^{[1
,2
]}

Ligler, Frances S. ^{[1
,2
]}

Cote, Gerard L. ^{[1
,2
,4
]}

Forster, Robert J. ^{[3
]}

Mabbott, Samuel ^{[1
,2
]}

机构：

[1] Texas A&M Univ, Dept Biomed Engn, 101 Bizzel St, College Stn, TX 77843 USA

[2] Texas A&M Engn Expt Stn, Ctr Remote Hlth Technol & Syst, 600 Discovery Dr, College Stn, TX 77840 USA

[3] Dublin City Univ, Sch Chem Sci, Glasnevin Campus, Dublin, Ireland

[4] Texas A&M Univ, Dept Elect Engn, College Stn, TX 77843 USA

来源：

BIOSENSORS & BIOELECTRONICS | 2025年 / 284卷

基金：

美国国家科学基金会; 爱尔兰科学基金会;

关键词：

Sensors; Biosensors; Alzheimer's disease; Parkinson's disease; Electrochemical detection; Optical detection; Advanced materials; Dementia diagnosis; AMYLOID-BETA; TOTAL TAU; BIOMARKER; INTEGRATION; SYNUCLEIN; DEVICE;

D O I：

10.1016/j.bios.2025.117535

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Early diagnosis by detecting ultralow concentrations of disease biomarkers is critical for timely treatment of the two most common neurodegenerative diseases, Alzheimer's and Parkinson's diseases. Innovative biosensors technologies can provide accurate, faster, and cheaper diagnostic pathways. In this review, the most recent electrochemical and optical sensing and biosensing platforms for diagnosing these diseases are critically selected and reviewed. Diagnostic targets (generally biomarkers) related to each disease and novel technologies, such as nanomaterials and biomolecular techniques to optimize the detection process and enhance signals, are discussed. In particular, multiplex detection and detection of multiple analytes by a (bio) sensing platform, to improve clinical sensitivity and selectivity are considered. This review is intended to open new approaches in the field and advance future research by identifying those strategies that optimize real-world performance and minimize present shortcomings.

引用

页数：22

共 182 条

[1] Blood GFAP as an emerging biomarker in brain and spinal cord disorders [J].

Abdelhak, Ahmed ;

Foschi, Matteo ;

Abu-Rumeileh, Samir ;

Yue, John K. ;

D'Anna, Lucio ;

Huss, Andre ;

Oeckl, Patrick ;

Ludolph, Albert C. ;

Kuhle, Jens ;

Petzold, Axel ;

Manley, Geoffrey T. ;

Green, Ari J. ;

Otto, Markus ;

Tumani, Hayrettin .

NATURE REVIEWS NEUROLOGY, 2022, 18 (03) :158-172

[2] Selective detection of alpha synuclein amyloid fibrils by faradaic and non-faradaic electrochemical impedance spectroscopic approaches [J].

Adam, Hussaini ;

Gopinath, Subash C. B. ;

Krishnan, Hemavathi ;

Adam, Tijjani ;

Fakhri, Makram A. ;

Salim, Evan T. ;

Shamsher, A. ;

Subramaniam, Sreeramanan ;

Chen, Yeng .

BIOELECTROCHEMISTRY, 2025, 161

[3] Cyclic and differential pulse voltammetric measurements on fibrils formation of alpha synuclein in Parkinson's disease by a gold interdigitated tetraelectrodes [J].

Adam, Hussaini ;

Gopinath, Subash C. B. ;

Krishnan, Hemavathi ;

Adam, Tijjani ;

Mohammed, Mohammed ;

Perumal, Veeradasan ;

Fakhri, Makram A. ;

Salim, Evan T. ;

Raman, Pachaiappan ;

Subramaniam, Sreeramanan ;

Chen, Yeng ;

Sasidharan, Sreenivasan .

PROCESS BIOCHEMISTRY, 2024, 136 :212-220

[4] Improving Multicolor Colocalization in Single-Vesicle Flow Cytometry with Vesicle Transit Time [J].

Andronico, Luca A. ;

Jung, Seung-Ryoung ;

Fujimoto, Bryant S. ;

Chiu, Daniel T. .

ANALYTICAL CHEMISTRY, 2023, 95 (28) :10492-10497

[5] Chitosan-enhanced sensitivity of mercaptoundecanoic acid (MUA)- capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha-synuclein oligomer biomarker in parkinson's disease [J].

Apaydin, Begum Balkan ;

Camoglu, Tugay ;

Ozdil, Zeliha Cansu Canbek ;

Gezen-Ak, Duygu ;

Ege, Duygu ;

Gulsoy, Murat .

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2025, 72 (01) :150-163

[6] Alzheimer's diagnosis beyond cerebrospinal fluid: Probe-Free Detection of Tau Proteins using MXene based redox systems and molecularly imprinted polymers [J].

Arjun, Ajith Mohan ;

Deshpande, Sudhaunsh ;

Dunlop, Tom ;

Norman, Beth ;

Oliviera, Daniela ;

Vulpe, Georgeta ;

Moreira, Felismina ;

Sharma, Sanjiv .

Biosensors and Bioelectronics: X, 2024, 20

[7] Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology [J].

Ashton, Nicholas J. ;

Brum, Wagner S. ;

Di Molfetta, Guglielmo ;

Benedet, Andrea L. ;

Arslan, Burak ;

Jonaitis, Erin ;

Langhough, Rebecca E. ;

Cody, Karly ;

Wilson, Rachael ;

Carlsson, Cynthia M. ;

Vanmechelen, Eugeen ;

Montoliu-Gaya, Laia ;

Lantero-Rodriguez, Juan ;

Rahmouni, Nesrine ;

Tissot, Cecile ;

Stevenson, Jenna ;

Servaes, Stijn ;

Therriault, Joseph ;

Pascoal, Tharick ;

Lleo, Alberto ;

Alcolea, Daniel ;

Fortea, Juan ;

Rosa-Neto, Pedro ;

Johnson, Sterling ;

Jeromin, Andreas ;

Blennow, Kaj ;

Zetterberg, Henrik .

JAMA NEUROLOGY, 2024, 81 (03) :255-263

[8] Ultrahigh-Throughput, Real-Time Flow Cytometry for Rare Cell Quantification from Whole Blood [J].

Aslan, Mahmut Kamil ;

Meng, Yingchao ;

Zhang, Yanan ;

Weiss, Tobias ;

Stavrakis, Stavros ;

deMello, Andrew J. .

ACS SENSORS, 2024, 9 (01) :474-482

[9] The duality of amyloid-β: its role in normal and Alzheimer's disease states [J].

Azargoonjahromi, Ali .

MOLECULAR BRAIN, 2024, 17 (01)

[10] Western blotting: a powerful staple in scientific and biomedical research [J].

Begum, Habeebunnisa ;

Murugesan, Periyasamy ;

Tangutur, Anjana Devi .

BIOTECHNIQUES, 2022, 73 (01) :59-69

← 1 2 3 4 5 6 7 8 9 10 →