Design Strategies for Hyaluronic Acid-based Drug Delivery Systems in Cancer Immunotherapy

被引：1

作者：

Rodella, Giulia ^{[1
,2
]}

Preat, Veronique ^{[1
]}

Gallez, Bernard ^{[2
]}

Malfanti, Alessio ^{[1
,3
]}

机构：

[1] UCLouvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, Ave Mounier 73 B1-73-12, B-1200 Brussels, Belgium

[2] UCLouvain, Louvain Drug Res Inst, Biomed Magnet Resonance, Ave Mounier 73 B1-73-08, B-1200 Brussels, Belgium

[3] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Via F Marzolo 5, I-35131 Padua, Italy

来源：

JOURNAL OF CONTROLLED RELEASE | 2025年 / 383卷

基金：

欧洲研究理事会;

关键词：

Hyaluronic acid; Drug delivery systems; Cancer immunotherapy; Immunomodulation; Vaccines; CD44; TUMOR-ASSOCIATED MACROPHAGES; MOLECULAR-WEIGHT; BREAST-CANCER; CD44-HYALURONAN INTERACTIONS; DENDRITIC CELLS; CD44; CLEAVAGE; EXPRESSION; NANOPARTICLES; RECEPTOR; CONJUGATE;

D O I：

10.1016/j.jconrel.2025.113784

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite its robust therapeutic potential, cancer immunotherapy has provided little progress towards improved survival rates for patients bearing immunologically refractory tumors. The implementation of advanced drug delivery systems represents a powerful means of improving cancer immunotherapy by relieving immunosuppression and promoting immune response; however, the overall impact of these systems on immunotherapy currently remains modest. Hyaluronic acid represents a widely used polymer in drug delivery; meanwhile, recent studies linking hyaluronic acid to the immune system make this polymer an attractive component in the design of next-generation cancer immunotherapies. Herein, we review our current understanding of the immunological properties of hyaluronic acid and discuss them in the context of bioactive functions and immune-related interactions with receptors, immune, and cancer cells. We analyze the potential of hyaluronic acid as a component in advanced drug delivery systems, highlighting strategies for the design of more effective vaccines and cancer chemo-immunotherapies. Finally, we discuss critical considerations to facilitate design and clinical translation to overcome existing challenges and maximize therapeutic potential.

引用

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