The effect of endocrine disruptors on the cardiovascular system: does sex matter?

被引：2
作者：
Assenza, Maria Rita [1 ]
Gaggi, Giulia [2 ,3 ,4 ]
Di Credico, Andrea [2 ,3 ,4 ]
Ghinassi, Barbara [2 ,5 ]
Barbagallo, Federica [1 ]
机构：
[1] Univ Enna Kore, Dept Med & Surg, I-94100 Enna, Italy
[2] Ctr Adv Studies & Technol CAST, Reprogramming & Cell Differentiat Lab, Chieti, Italy
[3] G Dannunzio Univ Chieti Pescara, Dept Med & Sci Aging, I-66100 Chieti, Pescara, Italy
[4] G Dannunzio Univ Chieti Pescara, UdA TechLab, I-66100 Chieti, Italy
[5] G Dannunzio Univ Chieti Pescara, Dept Innovat Technol Med & Dent, I-66100 Chieti, Italy
来源：
ENVIRONMENTAL RESEARCH | 2025年 / 277卷
关键词：
Endocrine disruptors; Heart; Cardiomyocytes; Sex differences; Animal model; Human; BISPHENOL-A EXPOSURE; FETAL CARDIAC DEVELOPMENT; HEART-RATE-VARIABILITY; PERFLUOROOCTANE SULFONATE; ESTROGEN-RECEPTOR; GENE-EXPRESSION; IN-UTERO; TOXICITY; HEALTH; MECHANISMS;
D O I：
10.1016/j.envres.2025.121612
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Endocrine disruptors (EDs) are environmental chemicals that interfere with hormone function, posing significant risks to human health, including the cardiovascular system. This review comprehensively examines the impact of EDs on cardiovascular health, with a specific focus on sex differences observed in various models. Utilizing invitro studies, in vivo animal models, and human clinical data, we delineate how sex-specific hormonal environments influence the cardiovascular effects of ED exposure. In vitro studies highlight cellular and molecular mechanisms that differ between male and female-derived cells. In vivo models reveal distinct physiological responses and susceptibilities to EDs, influenced by sex hormones. Human studies provide epidemiological evidence and clinical observations that underscore the variability in cardiovascular outcomes between men and women. This review underscores the necessity of considering sex as a critical factor in understanding the cardiovascular implications of ED exposure, advocating for gender-specific risk assessment and therapeutic strategies. The findings aim to enhance awareness and inform future research and policy-making to mitigate the adverse cardiovascular effects of EDs across different sexes.
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页数：12
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