Branched-chain amino acid and cancer: metabolism, immune microenvironment and therapeutic targets

被引：0

作者：

Xiong, Hao ^{[1
,2
]}

Liu, Ruiqi ^{[4
]}

Xu, Keke ^{[1
,2
]}

Chen, Xiaoyan ^{[1
]}

Huang, Luanluan ^{[1
]}

Shou, Yiyi ^{[1
]}

Huang, Yumei ^{[3
]}

Sheng, Hailong ^{[1
]}

Lu, Yanwei ^{[1
]}

Zhang, Haibo ^{[1
]}

机构：

[1] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Affiliated Peoples Hosp, Dept Radiat Oncol,Canc Ctr, Hangzhou, Zhejiang, Peoples R China

[2] Hangzhou Med Coll, Sch Basic Med Sci & Forens Med, Hangzhou, Zhejiang, Peoples R China

[3] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Affiliated Peoples Hosp, Dept Med Oncol,Canc Ctr, Hangzhou, Zhejiang, Peoples R China

[4] Tongde Hosp Zhejiang Prov, Dept Pathol, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2025年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

BCAA; Metabolic reprogramming; BCAT; Cancer; mTOR; GLUTAMIC-ACID; COPPER(II); PATHWAY; ENZYMES; LIGAND; BCKDK; BCAT1;

D O I：

10.1186/s12967-025-06664-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer is one of the major diseases threatening human health in the world. According to the latest global cancer statistics from the International Agency for Research on Cancer (IARC), there were approximately 20 million new cancer cases and 10 million cancer deaths worldwide. Amidst this global health concern, branched chain amino acids have emerged as key players, playing an important role in the occurrence and development of cancer. In certain malignancies like colorectal cancer, the average level of BCAA in tumor tissues is twice that in normal tissues. BCAA metabolism is intricately associated with the progression of multiple tumors and is modulated by diverse enzymes, including BCAT, BCKDH, and BCKDK. The metabolism of BCAA involves multiple enzymes and biochemical processes via signaling pathways such as PI3K/AKT/mTOR and AMPK/mTOR, etc. In addition, mTOR inhibitors show potential value in cancer treatment by regulating the metabolism and signaling pathways of tumor cells, which provides a new direction for anticancer efforts. Simultaneously, BCAAs are closely associated with tumor immunity, including NK cells, CD4+ T cells, and CD8+ T cells. At present, the research on BCAA metabolism and related enzymes and signaling pathways is still in progress, aiming at identifying new targets and ideas for cancer therapy, and combined therapy will become an important trend in the future. In this review, we discuss the role and mechanisms of BCAA metabolism in human cancer.

引用

页数：16

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