Application of biomarkers in the assessment and treatment of cancer-related fatigue

被引：0
作者：
Hui-Hui Hu [1 ]
Huan Zhao [6 ]
Yong-Jing Ren [1 ]
Sai-Qi Wang [2 ]
Zhe-Sheng Chen [1 ]
Hong Guo [1 ]
Yu-Hua He [3 ]
Xiao-Hui Gao [4 ]
Xiaobing Chen [5 ]
机构：
[1] Department of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hos
[2] Henan University of Traditional Chinese & Medicine Academy of Chinese Medicine Science, Henan Province, Zhengzhou City
[3] State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou
[4] Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Jamaica, 11439, NY
[5] Department of Gastroenterology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang
[6] Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang
来源：
Holistic Integrative Oncology | / 4卷 / 1期
基金：
中国国家自然科学基金;
关键词：
Biomarkers; Cancer-related fatigue; Exercise; Individualization; Inflammatory reaction; Oxidative stress; Treatment;
D O I：
10.1007/s44178-025-00167-3
中图分类号：
学科分类号：
摘要：
Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. This review summarizes the application of biomarkers in assessment and treatment of CRF, while exploring its biological basis through inflammatory pathways, neuroendocrine responses, metabolic disorders, mitochondrial dysfunction, and oxidative stress. Furthermore, the paper discusses the potential and value of biomarkers in CRF management, including therapeutic approaches such as psychostimulants, corticosteroids, nutritional supplements, and exercise interventions. The development of biomarkers offers a new perspective for the early identification, diagnosis, and treatment of CRF. © The Author(s) 2025.
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共 142 条
[91]  
Spathis A., Fife K., Blackhall F., Et al., Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial, J CLIN ONCOL, 32, pp. 1882-1888, (2014)
[92]  
Jean-Pierre P., Morrow G.R., Roscoe J.A., Et al., A phase 3 randomized, placebo-controlled, double-blind, clinical trial of the effect of modafinil on cancer-related fatigue among 631 patients receiving chemotherapy: a University of Rochester Cancer Center Community Clinical Oncology Program Research base study, CANCER-AM CANCER SOC, 116, pp. 3513-3520, (2010)
[93]  
Correa-Morales J.E., Cuellar-Valencia L., Mantilla-Manosalva N., Et al., Cancer and Non-cancer Fatigue Treated With Bupropion: A Systematic Review, J PAIN SYMPTOM MANAG, 65, pp. e21-e28, (2023)
[94]  
Yennurajalingam S., Bruera E., Role of corticosteroids for fatigue in advanced incurable cancer: is it a 'wonder drug' or 'deal with the devil, CURR OPIN SUPPORT PA, 8, pp. 346-351, (2014)
[95]  
Sandford A., Haywood A., Rickett K., Et al., Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer, Cochrane DB Syst Rev, 1, (2023)
[96]  
Hardy J., Haywood A., Rickett K., Sallnow L., Good P., Practice review: Evidence-based quality use of corticosteroids in the palliative care of patients with advanced cancer, PALLIATIVE MED, 35, pp. 461-472, (2021)
[97]  
Paulsen O., Klepstad P., Rosland J.H., Et al., Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: a randomized, placebo-controlled, double-blind trial, J CLIN ONCOL, 32, pp. 3221-3228, (2014)
[98]  
Yennurajalingam S., Valero V., Lu Z., Et al., Combination Therapy of Physical Activity and Dexamethasone for Cancer-Related Fatigue: A Phase II Randomized Double-Blind Controlled Trial, J NATL COMPR CANC NE, 20, pp. 235-243, (2021)
[99]  
Martinez-Alonso M., Dusso A., Ariza G., Nabal M., Vitamin D deficiency and its association with fatigue and quality of life in advanced cancer patients under palliative care: A cross-sectional study, PALLIATIVE MED, 30, pp. 89-96, (2016)
[100]  
Koole J.L., Bours M., van Roekel E.H., Et al., Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment, CANCER EPIDEM BIOMAR, 29, pp. 1135-1144, (2020)
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