Application of biomarkers in the assessment and treatment of cancer-related fatigue

被引：0
作者：
Hui-Hui Hu [1 ]
Huan Zhao [6 ]
Yong-Jing Ren [1 ]
Sai-Qi Wang [2 ]
Zhe-Sheng Chen [1 ]
Hong Guo [1 ]
Yu-Hua He [3 ]
Xiao-Hui Gao [4 ]
Xiaobing Chen [5 ]
机构：
[1] Department of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hos
[2] Henan University of Traditional Chinese & Medicine Academy of Chinese Medicine Science, Henan Province, Zhengzhou City
[3] State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou
[4] Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Jamaica, 11439, NY
[5] Department of Gastroenterology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang
[6] Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang
来源：
Holistic Integrative Oncology | / 4卷 / 1期
基金：
中国国家自然科学基金;
关键词：
Biomarkers; Cancer-related fatigue; Exercise; Individualization; Inflammatory reaction; Oxidative stress; Treatment;
D O I：
10.1007/s44178-025-00167-3
中图分类号：
学科分类号：
摘要：
Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. This review summarizes the application of biomarkers in assessment and treatment of CRF, while exploring its biological basis through inflammatory pathways, neuroendocrine responses, metabolic disorders, mitochondrial dysfunction, and oxidative stress. Furthermore, the paper discusses the potential and value of biomarkers in CRF management, including therapeutic approaches such as psychostimulants, corticosteroids, nutritional supplements, and exercise interventions. The development of biomarkers offers a new perspective for the early identification, diagnosis, and treatment of CRF. © The Author(s) 2025.
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