Safety and Immunogenic Efficacy of Inactivated Monovalent Vaccines against Newcastle Disease in the Republic of Kazakhstan

被引：0

作者：

Akmyrzayev, N. Zh. ^{[1
,2
]}

Assanzhanova, N. N. ^{[1
]}

Kydyrbayev, Zh. K. ^{[1
]}

Ryskeldinova, Sh. Zh. ^{[1
]}

Zhunushov, A. T. ^{[2
]}

Kozhamkulov, Ye. M. ^{[1
]}

Mailybayeva, A. M. ^{[1
]}

Sagymbayeva, A. M. ^{[1
]}

Myrzakhmetov, Ye. T. ^{[1
]}

机构：

[1] Res Inst Biol Safety Problems, Gvardeysky, Kazakhstan

[2] Natl Acad Sci Kyrgyz Republ, Inst Biotechnol, Bishkek, Kyrgyzstan

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2025年 / 178卷 / 06期

关键词：

Newcastle's disease; inactivated vaccine; harmlessness; immunogenicity; efficacy; SHEDDING FOLLOWING VACCINATION; INFLUENZA H9N2; VIRUS; OIL; TRANSMISSION; CHALLENGE;

D O I：

10.1007/s10517-025-06408-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effectiveness of the inactivated vaccines developed by us against the Newcastle disease virus was studied in chickens after infection with a highly virulent Alatau-98 strain. The vaccines in the form of a stable water-oil emulsion were prepared using Montanide ISA 70 VG adjuvant. The immunogenicity of the vaccines was checked 7, 14, 21, and 28 days after administration. The effectiveness was determined by the ability of the vaccine preparations to protect against the disease and by mortality after infection with a highly virulent Alatau-98 strain. Inactivated vaccines developed by us have shown promising results in protecting birds from Newcastle disease and can significantly improve disease control in domestic poultry.

引用

页码：739 / 743

页数：5

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