Beyond overweight, visceral adiposity is associated with estimation of cardiovascular risk in patients living with type 1 diabetes: findings from the SFDT1 cohort

被引：0

作者：

Salle, Laurence ^{[1
,2
,3
]}

Julla, Jean-Baptiste ^{[4
,5
,6
]}

Fagherazzi, Guy ^{[7
]}

Gourdy, Pierre ^{[8
,9
,10
]}

Bezerra Parente, Erika ^{[11
,12
,13
,14
,15
]}

Hanaire, Helene ^{[8
,16
]}

Tatulashvili, Sopio ^{[17
]}

Disse, Emmanuel ^{[18
,19
,20
]}

Franc, Sylvia ^{[21
]}

Hadjadj, Samy ^{[22
]}

Larger, Etienne ^{[23
,24
]}

Sanz, Caroline ^{[25
]}

Vaduva, Patricia ^{[26
]}

Valero, Rene ^{[27
,28
]}

Bonnefond, Amelie ^{[29
,30
,31
]}

Cosson, Emmanuel ^{[17
,32
,33
]}

Aguayo, Gloria A. ^{[7
]}

Riveline, Jean-Pierre ^{[4
,5
,6
]}

机构：

[1] Limoges Univ Hosp, Inserm 1094, Limoges, France

[2] Limoges Univ Hosp, IRD270, Limoges, France

[3] Dupuytren Univ Hosp, Hop Dupuytren 2, Dept Endocrinol Diabetol & Metab, 16 Rue Prof DESCOTTES, F-87042 Limoges, France

[4] Univ Paris Cite, Inst Necker Enfants Malad INEM, INSERM, CNRS,INEM, F-75015 Paris, France

[5] Lariboisiere Hosp, AP HP, Dept Diabet, Paris, France

[6] Paris Cite Univ, Paris, France

[7] Luxembourg Inst Hlth, Dept Precis Hlth, Deep Digital Phenotyping Res Unit, GAA,GF, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg

[8] Toulouse Univ Hosp, Dept Diabetol Metab Dis & Nutr, Toulouse, France

[9] INSERM, Inst Metab & Cardiovasc Dis, Toulouse, France

[10] Toulouse Univ, I2MC, UMR1297, Toulouse, France

[11] Folkhalsan Res Ctr, Biomed Helsinki, Helsinki, Finland

[12] Univ Helsinki, Res Program Clin & Mol Metab, Helsinki, Finland

[13] Univ Helsinki, Dept Nephrol, Helsinki, Finland

[14] Helsinki Univ Hosp, Helsinki, Finland

[15] Boehringer Ingelheim Int GmbH, Ingelheim, Germany

[16] Toulouse Univ, Toulouse, France

[17] Univ Paris 13, Avicenne Hosp, AP HP, Dept Endocrinol Diabetol Nutr,Sorbonne Paris Cite,, Bobigny, France

[18] Hop Lyon Sud, Dept Endocrinol Diabet & Nutr, Hosp Civils Lyon, F-69390 Lyon, France

[19] Univ Claude Bernard Lyon 1, Univ Lyon, CarMeN lab, INSA Lyon,INRA,INSERM, F-1,69495 Pierre Benite, France

[20] INSERM, FORCE Network, F CRIN Network, French Obes Res Ctr Excellence, Lyon, France

[21] Sud Francilien Hosp, Dept Endocrinol, DiabetologyCorbeil Essonnes, Corbeil Essonnes, France

[22] Nantes Univ, Nantes Univ Hosp Ctr, Thorax Inst, CNRS,INSERM, Nantes, France

[23] Cochin Hosp, Diabetol Dept, AP HP, Paris, France

[24] Paris Cite Univ, Cochin Inst, INSERM, U1016, Paris, France

[25] Clin Pasteur, Dept Diabetol & Endocrinol, Toulouse, France

[26] Rennes Univ Hosp, Dept Endocrinol Diabet & Nutr, F-35000 Rennes, France

[27] Aix Marseille Univ, Univ Hosp Conception, APHM, INSERM,C2VN, Marseille, France

[28] Dept Nutr Metab Dis & Endocrinol, 147 Blvd Baille, F-13005 Marseille, France

[29] Pasteur Inst Lille, EGID, CNRS, Inserm,UMR 1283 8199, Lille, France

[30] Univ Lille, Lille Univ Hosp, Lille, France

[31] Imperial Coll London, Hammersmith Hosp, Dept Metab, London, England

[32] Univ Sorbonne Paris Nord, Ctr Res Epidemiol & Stat CRESS, Nutr Epidemiol Res Team EREN, F-93017 Bobigny, France

[33] Univ Paris Cite, INSERM, INRAE, CNAM, F-93017 Bobigny, France

来源：

CARDIOVASCULAR DIABETOLOGY | 2025年 / 24卷 / 01期

关键词：

Cardiovascular risk; Body mass index; Type; 1; diabetes; Adiposity distribution; Sex; Waist circumference; Registry; BODY-MASS INDEX; TO-HEIGHT RATIO; WAIST CIRCUMFERENCE; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; SUBCUTANEOUS FAT; SCREENING TOOL; ABDOMINAL FAT; DISEASE; MORTALITY;

D O I：

10.1186/s12933-025-02789-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction & Objectives As in the general population, people living with type 1 diabetes (PWT1D) are faced with overweight and obesity, which contribute to cardiovascular (CV) risk. However, the role of visceral adiposity, due to its adverse metabolic profile, should also be addressed in PWT1D. We aimed to assess the 10-year CV risk of PWT1D according to body mass index (BMI) and waist-to-height ratio (WHtR), a parameter for estimating visceral adiposity. Methods In this cross-sectional study, PWT1D in primary CV prevention from the SFDT1 cohort were categorized by BMI status, either normal (18.5-24.9 kg/m2) or overweight/obesity (>= 25 kg/m2), and by WHtR according to the validated threshold of 0.5. The 10-year CV risk was estimated using the Steno Type 1 Risk Engine and classified into three categories: low (< 10%), intermediate (10-20%) and high (> 20%). The distribution of CV risk was assessed using density plots. In multivariable analysis, the association between BMI, WHtR, and high estimated 10-year CV risk was studied using spline regression models with sex stratification. Thresholds were determined by the Receiver Operating Characteristic (ROC) curve. Results The study included 1,482 patients; 49.9% had a normal BMI, and 50.1% a BMI >= 25 kg/m2. The proportion of patients with high CV risk was higher in PWT1D with overweight/obesity (12% vs. 7%) and in those with WHtR >= 0.5 (13% vs. 4%). BMI was significantly associated with high CV risk in men (p = 0.001) but a non-significant trend was found in women (p = 0.053). WHtR was significantly associated with high CV risk in both men (p < 0.001) and women (p = 0.046). The BMI threshold associated with high CV risk was 24.9 kg/m2 for men, and the WHtR threshold was 0.5 for both men and women. Conclusion In PWT1D in condition of primary CV prevention, visceral adiposity, assessed by WHtR, is a more robust marker of estimated 10-year CV risk than overweight/obesity status in both men and women.

引用

页数：12

共 46 条

[1] Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis [J].