Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation

被引：0

作者：

Edith Nathalie Pineda ^{[1
]}

Bernice Nounamo ^{[1
]}

Ruofei Du ^{[2
]}

Enoch K. Larrey ^{[1
]}

Cordell Gilreath ^{[1
]}

Harrison Cook ^{[1
]}

Marjan Boerma ^{[1
]}

Igor Koturbash ^{[2
]}

Rupak Pathak ^{[1
]}

机构：

[1] University of Arkansas for Medical Sciences,Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy

[2] University of Arkansas for Medical Sciences,College of Public Health

来源：

npj Microgravity | / 11卷 / 1期

关键词：

D O I：

10.1038/s41526-025-00480-1

中图分类号：

学科分类号：

摘要：

Given NASA’s plans for manned lunar and Mars missions, it is critical to assess the risk of splenic immune dysregulation by using ground-based models of simulated microgravity (SMG) and/or chronic irradiation (CIR). To address this, C57BL/6 J mice of both sexes exposed to SMG and/or CIR for 29 days and alterations in immune cell distribution, function and phenotype were assessed. SMG and/or CIR altered a greater variety of immune cells in both lymphoid and myeloid lineages in female mice than in male mice; the function of splenic CD4 + T cells, CD8 + T cells, and CD19 + B cells altered in a sex-specific manner; and the distribution of different immune cells altered based on animal sex. These findings indicate that SMG and/or CIR alter the splenic immune cell distribution, phenotype and function in a sex-specific manner, underscoring the need for tailored strategies to mitigate health risks for crew members on long-term deep-space missions.

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