Serum Selenium Levels and Lipid Profile: A Systematic Review and Meta-analysis of Observational StudiesSerum Selenium Levels and Lipid Profile: A Systematic Review and Meta-analysis of Observational Studies

被引：0

作者：

Sadegh Mazaheri-Tehrani ^{[1
]}

Amir Parsa Abhari ^{[2
]}

Negar Ostadsharif ^{[3
]}

Arman Shekarian ^{[4
]}

Mahshad Vali ^{[3
]}

Elahe Saffari ^{[5
]}

Kasra Talebi Anaraki ^{[6
]}

Mohammad Ali Haghighatpanah ^{[5
]}

Mohammad Fakhrolmobasheri ^{[1
]}

Marek Kieliszek ^{[7
]}

机构：

[1] Research Institute for Primordial Prevention of Non-Communicable Disease,Child Growth and Development Research Center

[2] Isfahan University of Medical Sciences,Student Research Committee

[3] Cardiovascular Research Institute,Heart Failure Research Center

[4] Isfahan University of Medical Sciences,School of Medicine

[5] Isfahan University of Medical Sciences,Department of Cardiovascular Surgery

[6] Isfahan Cardiovascular Research Institute,Department of Food Biotechnology and Microbiology

[7] Isfahan University of Medical Sciences,undefined

[8] Isfahan Endocrine and Metabolism Research Center,undefined

[9] Isfahan University of Medical Sciences,undefined

[10] Isfahan University of Medical Sciences,undefined

[11] Chamran Heart Center,undefined

[12] Isfahan University of Medical Sciences,undefined

[13] Institute of Food Sciences,undefined

[14] Warsaw University of Life Sciences—SGGW,undefined

来源：

Biological Trace Element Research | 2025年 / 203卷 / 5期

关键词：

Lipid profile; Triglycerides; Selenium; Low-density lipoprotein; High-density lipoprotein; Total cholesterol;

D O I：

10.1007/s12011-024-04365-4

中图分类号：

学科分类号：

摘要：

Selenium is a trace element with pivotal roles in metabolic processes. Studies suggested that selenium deficiency could lead to impaired lipid profiles. However, inconsistent results have been reported regarding the association between serum selenium concentrations and lipid profile (triglycerides, LDL, HDL, VLDL, and total cholesterol). Thus, we aimed to review the correlation between them. A systematic literature search was conducted in PubMed, Embase, Web of Science, Scopus, and Google Scholar until 31 December 2023. The relevant correlation coefficients were used as desired effect sizes to assess the correlation between selenium level and lipid profile. Among 8291 records found in the primary search, 47 and 34 articles were included in the systematic review and meta-analysis, respectively. All included studies were observational investigations and had acceptable quality. Our results failed to reach strong evidence supporting the correlation between serum selenium level and lipid profiles, except for HDL, which showed a weak correlation among both adults (r = 0.1 [0.03:0.17]; I2 = 71%) and pediatrics (r = 0.08 [0.03:0.14]; I2 = 38%). Subgroup analyses based on gender did not reveal a significant or strong correlation with selenium levels (except for total cholesterol in males (r = 0.12 [0.01:0.22]; I2 = 52%)). The results did not change after the sensitivity analysis. Although some previous studies have suggested that selenium deficiency could lead to impaired lipid profile, the findings of this study indicate no strong correlation between serum selenium levels and lipid profile.

引用

页码：2517 / 2538

页数：21