Unfavorable impact of female gender on outcomes following aortic valve replacement combined with coronary artery bypass grafting

被引：0

作者：

Bartłomiej Perek ^{[1
]}

Sleiman Sebastian Aboul-Hassan ^{[2
]}

Tomasz Hrapkowicz ^{[3
]}

Radosław Gocoł ^{[4
]}

Marek Deja ^{[5
]}

Bogusław Kapelak ^{[5
]}

Jan Rogowski ^{[6
]}

Kazimierz Widenka ^{[7
]}

Marcin Krasoń ^{[8
]}

Bohdan Maruszewski ^{[4
]}

Romuald Cichoń ^{[9
]}

Marek Jemielity ^{[2
]}

Marek Jasiński ^{[3
]}

机构：

[1] Poznan University of Medical Sciences,Department of Cardiac Surgery and Transplantology

[2] University of Zielona Gora,Department of Cardiac Surgery and Interventional Cardiology, Faculty of Medicine and Medical Sciences

[3] Zbigniew Religa Heart Center ‘Medinet’,Department of Cardiac Surgery

[4] Medical University of Silesia in Katowice,Department of Cardiac Surgery, Transplantology, Vascular and Endovascular Surgery, Silesian Centre for Heart Diseases

[5] Medical University of Silesia,Department of Cardiac Surgery

[6] Jagiellonian University Medical College,Department of Cardiovascular Surgery and Transplantology, Institute of Cardiology

[7] Medical University of Gdansk,Department of Cardiac and Vascular Surgery

[8] University of Rzeszow,Department of Cardiac Surgery

[9] The Children’s Memorial Health Institute,Department of Pediatric Cardiothoracic Surgery

[10] Wroclaw Medical University,Department and Clinic of Cardiac Surgery

来源：

Scientific Reports | / 15卷 / 1期

关键词：

Coronary artery disease; Aortic valve; Coronary artery bypass grafting; Aortic valve replacement; Outcomes;

D O I：

10.1038/s41598-025-02892-1

中图分类号：

学科分类号：

摘要：

Despite widespread implementation of intravascular techniques in cardiovascular medicine, combined aortic valve replacement (AVR) and coronary artery bypass grafting (CABG) have still been standard of surgical treatment. A purpose of this multicenter retrospective cohort study was to assess an impact of female sex on early outcomes and late survival rate following simultaneous AVR + CABG. This study comprised 12,626 patients (30.1% females; 69.9% males) that underwent AVR + CABG in 2006 through 2020. Primary endpoint was late survival. Thirty-day mortality and morbidity rates were also evaluated. In order to reduce an impact of inherent confounders, a propensity score (PS) matching was applied. PS matching selected 3,443 pairs and both gender groups were well balanced for baseline and operative characteristics. Women had higher 30-day mortality (OR: 1.42 (1.17–1.73), p < 0.001), more prevalent respiratory failure (OR: 1.28 (1.06–1.55), p = 0.01) and increased risk of postoperative application of cardiac support devices (OR: 1.46 (1.09–1.94), p = 0.01), but reduced incidence of re-thoracotomy due to bleeding compared to men (OR: 0.8 (0.67–0.95), p = 0.01). A probability of survival of 4-year (76.2 vs. 76.1%) and 8-year (58.8 vs. 57.0%) follow-up was comparable between females and males, respectively. Women undergoing aortic valve replacement with concomitant artery bypass grafting presented worse early outcomes but comparable long-term survival to men.

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