Interdialytic blood pressure variability and all-cause mortality in patients undergoing maintenance hemodialysis: a multicenter study using DialysisNet

Background/aimsIn this study, we aimed to analyze all-cause mortality according to interdialytic blood pressure variability (BPV) in patients undergoing hemodialysis.MethodsData on predialysis blood pressure (BP) and clinical information were extracted from four dialysis units through the DialysisNet system, which enables efficient hemodialysis management using common data elements. Interdialytic BPV was evaluated as the coefficient of variation (CV) of predialysis BP at each dialysis session over a 12-month period. The CV of systolic BP (SBP) and diastolic BP (DBP) was divided into tertiles. The primary outcome was all-cause mortality according to the CV of predialysis SBP, which was analyzed using Cox regression analysis.ResultsThe data of 357 patients undergoing hemodialysis were analyzed. Compared with the first SBP CV tertile, the third tertile showed significantly increased all-cause mortality after adjustment (hazard ratio [HR], 2.11; 95% confidence interval [CI] 1.04-4.24). Compared with the first DBP CV tertile, the third tertile showed significantly increased mortality in univariable analysis (HR, 2.18; 95% CI 1.10-4.30) but not in multivariable analysis (HR, 1.88; 95% CI 0.89-3.95).ConclusionsIncreased interdialytic BPV in patients undergoing hemodialysis is associated with all-cause mortality. This was more prominent in SBP than in DBP. Particular attention should be paid to large BPVs in older adults, women, and patients with a relatively longer dialysis vintage.