An energy metabolism-related signature relevant to the tumor immune microenvironment in HNSCC

被引：0

作者：

Zhu, Kaiyu ^{[1
,2
,3
]}

Bai, Yang ^{[3
,4
]}

Lin, Changwei ^{[3
]}

Song, Guilin ^{[1
]}

Chen, Yifei ^{[1
]}

机构：

[1] Hunan Normal Univ, Hosp Changsha 4, Integrated Tradit Chinese & Western Med Hosp Chang, Dept Otolaryngol Head Neck Surg,Changsha Hosp, 200 Jinxing North Rd, Changsha 410219, Hunan, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Ctr Gastrointestinal Surg, Guangzhou 510080, Peoples R China

[3] Cent South Univ, Dept Gastrointestinal Surg, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 3, Postdoctoral Stn Basic Med, Changsha 410013, Hunan, Peoples R China

来源：

DISCOVER ONCOLOGY | 2025年 / 16卷 / 01期

关键词：

Energy metabolism; Head and neck squamous cell carcinoma; Prognostic signature; Tumor immune microenvironment; DSG2; SQUAMOUS-CELL CARCINOMA; HEAD; CANCER; EXPRESSION; GLUCOSE;

D O I：

10.1007/s12672-025-02652-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The importance of energy metabolism in cancer was explored by accumulating studies. Energy metabolism can affect the cellular activities of tumors. However, there is few research exploring the role of energy metabolism in tumor immune microenvironment. In this context, we constructed a novel energy metabolism-related prognostic signature containing 8 genes. The risk score calculated by the signature was analyzed to be an independent value of head and neck squamous cell carcinoma (HNSCC). We further validated the effectiveness and accuracy of our signature in The Cancer Genome Atlas Program (TCGA) cohort and Gene Expression Omnibus (GEO) cohort. Moreover, we also revealed a negative correlation between the risk score and the activity of the immune processes. Finally, we validated the function of Desmoglein 2 protein (DSG2), a risk gene in the signature, in tumor progression and found that knockdown of DSG2 remarkably suppressed the proliferation and migration of HNSCC cells, which further validated our analysis. In conclusion, the energy metabolism-related gene signature we built is a prospective biomarker of HNSCC, which can offer valuable clues for the research and development of immunotherapeutic drugs in HNSCC.

引用

页数：23

共 51 条

[1]

[Anonymous], **DATA OBJECT**

[2] Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth [J].

Badeaux, Mark D. ;

Rolig, Annah S. ;

Agnello, Giulia ;

Enzler, Danlee ;

Kasiewicz, Melissa J. ;

Priddy, Leslie ;

Wiggins, Jason F. ;

Muir, Alexander ;

Sullivan, Mark R. ;

Van Cleef, Jessica ;

Daige, Christopher ;

Vander Heiden, Matthew G. ;

Rajamanickam, Venkatesh ;

Wooldridge, James E. ;

Redmond, William L. ;

Rowlinson, Scott W. .

CANCER IMMUNOLOGY RESEARCH, 2021, 9 (04) :415-429

[3] SnapShot: TCGA-Analyzed Tumors [J].

Blum, Amy ;

Wang, Peggy ;

Zenklusen, Jean C. .

CELL, 2018, 173 (02) :530-530

[4] Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer [J].

Chang, Po-Hao ;

Chen, Min-Che ;

Tsai, Ya-Ping ;

Tan, Grace Y. T. ;

Hsu, Pang-Hung ;

Jeng, Yung-Ming ;

Tsai, Yi-Fang ;

Yang, Muh-Hwa ;

Hwang-Verslues, Wendy W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (03)

[5]

Chen BB, 2018, METHODS MOL BIOL, V1711, P243, DOI 10.1007/978-1-4939-7493-1_12

[6] Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies [J].

Chen, Zhichun ;

Zhong, Chunjiu .

PROGRESS IN NEUROBIOLOGY, 2013, 108 :21-43

[7] A Feed-Forward Loop Involving Protein Kinase Cα and MicroRNAs Regulates Tumor Cell Cycle [J].

Cohen, Ezra E. W. ;

Zhu, Hongyan ;

Lingen, Mark W. ;

Martin, Leslie E. ;

Kuo, Wen-Liang ;

Choi, Eugene A. ;

Kocherginsky, Masha ;

Parker, Joel S. ;

Chung, Christine H. ;

Rosner, Marsha Rich .

CANCER RESEARCH, 2009, 69 (01) :65-74

[8] Immunology and Immunotherapy of Head and Neck Cancer [J].

Ferris, Robert L. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (29) :3293-+

[9] pRRophetic: An R Package for Prediction of Clinical Chemotherapeutic Response from Tumor Gene Expression Levels [J].

Geeleher, Paul ;

Cox, Nancy ;

Huang, R. Stephanie .

PLOS ONE, 2014, 9 (09)

[10] The reactome pathway knowledgebase 2022 [J].

Gillespie, Marc ;

Jassal, Bijay ;

Stephan, Ralf ;

Milacic, Marija ;

Rothfels, Karen ;

Senff-Ribeiro, Andrea ;

Griss, Johannes ;

Sevilla, Cristoffer ;

Matthews, Lisa ;

Gong, Chuqiao ;

Deng, Chuan ;

Varusai, Thawfeek ;

Ragueneau, Eliot ;

Haider, Yusra ;

May, Bruce ;

Shamovsky, Veronica ;

Weiser, Joel ;

Brunson, Timothy ;

Sanati, Nasim ;

Beckman, Liam ;

Shao, Xiang ;

Fabregat, Antonio ;

Sidiropoulos, Konstantinos ;

Murillo, Julieth ;

Viteri, Guilherme ;

Cook, Justin ;

Shorser, Solomon ;

Bader, Gary ;

Demir, Emek ;

Sander, Chris ;

Haw, Robin ;

Wu, Guanming ;

Stein, Lincoln ;

Hermjakob, Henning ;

D'Eustachio, Peter .

NUCLEIC ACIDS RESEARCH, 2022, 50 (D1) :D687-D692

← 1 2 3 4 5 6 →