Photoredox/Nickel-Catalyzed Cross-Coupling of Alkynyl Bromides and α-Silylamines for the Synthesis of Propynylamines

被引：2

作者：

Ye, Fu ^{[1
]}

Gao, Wei ^{[1
]}

Liu, Peiwen ^{[1
]}

Yuan, Weiming ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol HUST, Sch Chem & Chem Engn, Key Lab Mat Chem Energy Convers & Storage, Hubei Key Lab Bioinorgan Chem & Mat Med,Minist Edu, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

来源：

CHEMCATCHEM | 2025年 / 17卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Cross-coupling; Nickel; Photoredox; Propargylamines; Radical; BONDS;

D O I：

10.1002/cctc.202500106

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Propynylamines are prevalent structures widely existing in biologically active compounds and natural products. In this study, we present a novel alkynylation approach for synthesizing propargylamines by cross-coupling of alkynyl bromides and alpha-silylamines via a nickel metallaphotoredox catalysis. A diverse range of N-heterocyclic and acyclic alpha-silylamines, along with aromatic and aliphatic alkynyl bromides, are nicely incorporated, delivering structurally diverse propargylamines in moderate to good yields. Mechanistic studies suggest that the reaction proceeds through a radical pathway.

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页数：5

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