Cyclodextrin-Based Inclusion Complexes Improve the In Vitro Solubility and Pharmacokinetics of Ivacaftor Following Oral Administration in Mice

被引：0

作者：

David S. Nakhla ^{[1
]}

Youssef W. Naguib ^{[1
]}

Sanjib Saha ^{[1
]}

Dylan Gao ^{[1
]}

Nikesh Gupta ^{[1
]}

Walla Malkawi ^{[1
]}

Timothy M. Acri ^{[1
]}

Aliasger K. Salem ^{[1
]}

机构：

[1] University of Iowa,Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy

[2] University of Iowa,Holden Comprehensive Cancer Center

来源：

关键词：

cyclodextrin; cystic fibrosis; CFTR; ivacaftor; inclusion complex;

D O I：

10.1208/s12249-025-03131-6

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学科分类号：

摘要：

引用