Synthesis and Antimicrobial Activity of Substituted Amino-1H-Pyrazoles

被引：0

作者：

Meshcheryakova, A. A. ^{[1
]}

Konstantinova, E. A. ^{[1
,2
]}

Borisova, S. V. ^{[3
]}

Burygin, G. L. ^{[1
,2
]}

Sorokin, V. V. ^{[1
]}

机构：

[1] Chernyshevsky Saratov Natl Res State Univ, Inst Chem, 83 Astrakhanskaya St, Saratov 410012, Russia

[2] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Autonomous Struct Subdiv FRC Saratov Sci Ctr, 13 Prosp Entuziastov, Saratov 410049, Russia

[3] VI Razumovsky Saratov State Med Univ, Minist Hlth Russia, 112 Bolshaya Kazachya St, Saratov 410012, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2025年 / 59卷 / 01期

关键词：

substituted amino-1H-pyrazolecarbonitriles; substituted amino-1H-pyrazolecarboxamides; three-component one-step synthesis; antibacterial activity; 3-COMPONENT SYNTHESIS; POLARIZED ETHYLENES; PYRAZOLES; DITHIOCARBOXYLATES; INHIBITORS; THIOAMIDES;

D O I：

10.1007/s11094-025-03358-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substituted amino-1H-pyrazoles have been synthesized and characterized in terms of their antimicrobial ac- tivity. A three-component synthesis was carried out using a simple environmentally friendly one-step method starting from aromatic aldehydes, hydrazines or benzhydrazides, malononitrile or cyanoacetic acid amide and water or a mixture of water-i-PrOH as the solvent. The antimicrobial properties of the synthesized com- pounds, including previously unknown ones, were determined against Gram-negative and Gram-positive bac- teria. 5-Amino-1-(2,4-dinitrophenyl)-3-aryl-1H-pyrazole-4-carboxylates with 3-nitrophenyl or 3-hydroxy- phenyl substituents showed pronounced antimicrobial activity against Pseudomonas aeruginosa. The results indicated that further searching for antimicrobial compounds in the series of aryl-substituted amino-1H-pyrazolecarbonitriles and amino-1H-pyrazolecarboxamides was promising.

引用

页码：21 / 26

页数：6

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