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Comment on “A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children”
被引：0
作者：
Jiajing Wang
[1
]
机构：
[1] Southern Medical University,Department of Anesthesiology, Nanfang Hospital
[2] The key Laboratory of Precision Anesthesia & perioperative Organ Protection,Department of Anesthesiology, Zengcheng Campus Nanfang Hospital
[3] Southern Medical University,undefined
关键词：
Dexmedetomidine;
Esketamine;
Children;
Sample size;
Sedation;
D O I：
10.1186/s13049-025-01403-5
中图分类号：
学科分类号：
摘要：
This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09), necessitating larger trials. Safety concerns (e.g., aspiration risk), unaddressed long-term psychological outcomes, and limited pharmacokinetic data (delayed DEX onset, prolonged duration) challenge clinical applicability. Future studies should integrate objective measures and long-term follow-up.
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