Giant angiomyofibroblastoma of the scrotum: a case report and review of the literature

Background: An angiomyofibroblastoma (AMF) is a rare tumor that primarily occurs in the vulva of women. AMF rarely occurs in the inguinal region and scrotum of men. Case presentation: A 59-year-old male was admitted to the hospital for evaluation of left scrotal enlargement for 2 years. A physical examination revealed no elevation in the bilateral renal or suprapubic region. The bladder was located below the pubic bone and was non- tender without pressure. Auscultation revealed no abnormalities in the right or left renal regions. The left scrotum was enlarged with a palpable mass measuring 25 × 15 cm in size. The mass was characterized by a tough, smooth surface with a clear boundary. The left testis was not palpable and the transillumination test result was negative. Magnetic resonance imaging included an abnormal signal in the scrotum, which was consistent with a space-occupying germ cell tumor but other diagnoses could not be ruled out. The preoperative preparation indicated no contraindications to surgery. Under lumbar anesthesia, the left scrotal lesion was resected. The postoperative pathologic evaluation confirmed an AMF. Currently, the patient has recovered fully without complications. Conclusion: A large-sized AMF is relatively rare in the male scrotum, but reported in this case. A scrotal AMF often has an oval shape with no palpable pain. Imaging techniques can facilitate the hypervascular status of an AMF and pathologic findings can establish the diagnosis. However, reports of scrotal AMF are limited. A more thorough understanding should be achieved with additional cases and long-term follow-up. © The Author(s) 2025.