The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2/IL-2R signaling axis

被引：0
|
作者：
L. Tatiana Albarracin Melo [1 ]
Nekruz Abdulkhakov [2 ]
Irina Han [1 ]
Ali El-Bizri [2 ]
Monika Brunner-Weinzierl [3 ]
Burkhart Schraven [1 ]
Luca Simeoni [2 ]
机构：
[1] Institute of Molecular and Clinical Immunology,Department of Experimental Pediatrics
[2] Medical Faculty,undefined
[3] University Hospital,undefined
[4] Otto-Von Guericke University,undefined
[5] Health Campus Immunology,undefined
[6] Infectiology and Inflammation (GC-I3),undefined
[7] Medical Faculty,undefined
[8] University Hospital,undefined
[9] Otto-Von Guericke University,undefined
[10] Medical Faculty,undefined
[11] University Hospital,undefined
[12] Otto-Von-Guericke-University,undefined
来源：
Cell Communication and Signaling | / 23卷 / 1期
关键词：
Glucocorticoids; T cells; Immunosuppression; IL-2 signaling; TCR signaling; Jak/STAT pathway; Erk1/2 activation; IκB activation;
D O I：
10.1186/s12964-025-02266-0
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