The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2/IL-2R signaling axis

被引：0
|
作者：
L. Tatiana Albarracin Melo [1 ]
Nekruz Abdulkhakov [2 ]
Irina Han [1 ]
Ali El-Bizri [2 ]
Monika Brunner-Weinzierl [3 ]
Burkhart Schraven [1 ]
Luca Simeoni [2 ]
机构：
[1] Institute of Molecular and Clinical Immunology,Department of Experimental Pediatrics
[2] Medical Faculty,undefined
[3] University Hospital,undefined
[4] Otto-Von Guericke University,undefined
[5] Health Campus Immunology,undefined
[6] Infectiology and Inflammation (GC-I3),undefined
[7] Medical Faculty,undefined
[8] University Hospital,undefined
[9] Otto-Von Guericke University,undefined
[10] Medical Faculty,undefined
[11] University Hospital,undefined
[12] Otto-Von-Guericke-University,undefined
来源：
Cell Communication and Signaling | / 23卷 / 1期
关键词：
Glucocorticoids; T cells; Immunosuppression; IL-2 signaling; TCR signaling; Jak/STAT pathway; Erk1/2 activation; IκB activation;
D O I：
10.1186/s12964-025-02266-0
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 49 条
  • [1] Editorial: IL-2/IL-2R axis modulation by mesenchymal stromal cells: interaction with immunosuppressive drugs?
    Ballester, Sara
    Ballester, Alicia
    JOURNAL OF LEUKOCYTE BIOLOGY, 2017, 101 (03) : 617 - 619
  • [2] An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CART cells and clearance of bulky lymphoma
    Aspuria, Paul-Joseph
    Vivona, Sandro
    Bauer, Michele
    Semana, Marie
    Ratti, Navneet
    McCauley, Scott
    Riener, Romina
    Malefyt, Rene de Waal
    Rokkam, Deepti
    Emmerich, Jan
    Kastelein, Rob A.
    Lupardus, Patrick J.
    Oft, Martin
    SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (625)
  • [3] Expression of the IL-2R in Human Podocytes and the Effect of Activation on Autophagy and Apoptosis
    Stewart, Tyrus
    Zea, Arnold
    Aviles, Diego
    FETAL AND PEDIATRIC PATHOLOGY, 2021, 40 (05) : 369 - 377
  • [4] Human IL-2Rα subunit binding modulation of IL-2 through a decline in electrostatic interactions: A computational and experimental approach
    Parikhani, Arezoo Beig
    Bagherzadeh, Kowsar
    Dehghan, Rada
    Biglari, Alireza
    Shokrgozar, Mohammad Ali
    Rad, Farhad Riazi
    Zeinali, Sirous
    Talebkhan, Yeganeh
    Ajdary, Soheila
    Cohan, Reza Ahangari
    Behdani, Mahdi
    PLOS ONE, 2022, 17 (02):
  • [5] Microvesicles released by apoptotic human neutrophils suppress proliferation and IL-2/IL-2 receptor expression of resting T helper cells
    Shen, Guifen
    Krienke, Stefan
    Schiller, Petra
    Niessen, Anna
    Neu, Susanne
    Eckstein, Volker
    Schiller, Martin
    Lorenz, Hanns-Martin
    Tykocinski, Lars-Oliver
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2017, 47 (05) : 900 - 910
  • [6] IL-2 PROMOTER-DRIVEN LACZ EXPRESSION AS A MONITORING TOOL FOR IL-2 EXPRESSION IN PRIMARY T-CELLS OF TRANSGENIC MICE
    BROMBACHER, F
    SCHAFER, T
    WEISSENSTEIN, U
    TSCHOPP, C
    ANDERSEN, E
    BURKI, K
    BAUMANN, G
    INTERNATIONAL IMMUNOLOGY, 1994, 6 (02) : 189 - 197
  • [7] IL-2 and TCR stimulation induce expression and secretion of IL-32β by human T cells
    Sanna, Franziska Christine
    Benesova, Iva
    Pervan, Philip
    Krenz, Adriana
    Wurzel, Alexander
    Lohmayer, Robert
    Muehlbauer, Jasmin
    Woellner, Amelie
    Koehl, Nina
    Menevse, Ayse Nur
    Stamova, Slava
    Volpin, Valentina
    Beckhove, Philipp
    Xydia, Maria
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [8] Increased sIL-2Rα leads to obstruction of IL-2 biological function and Treg cells differentiation in SLE patients via binding to IL-2
    Long, Dan
    Yu, Shujiao
    Zhang, Lu
    Guo, Yang
    Xu, Shumin
    Rao, Yuting
    Huang, Zikun
    Luo, Qing
    Li, Junming
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [9] Quantitative assessment concerning the contribution of IL-2Rβ for superantigen-mediated T cell responses in vivo
    Jin, HL
    Gong, DP
    Adeegbe, D
    Bayer, AL
    Rolle, C
    Yu, AX
    Malek, TR
    INTERNATIONAL IMMUNOLOGY, 2006, 18 (04) : 565 - 572
  • [10] EFFECT OF IL-2 ON PROLIFERATION AND APOPTOSIS OF PROSTATIC HYPERPLASIA EPITHELIAL CELLS VIA THE ERK1/2 SIGNALING PATHWAY
    Guo, Wei
    Jiang, Wei
    Xu, Zhen
    Ruan, Yashi
    ACTA MEDICA MEDITERRANEA, 2022, 38 (01): : 167 - 172
12345