Personalized Care for Pancreatic Cancer: Harnessing Patient-Derived Organoids

被引：0
作者：
L. Demyan [1 ]
M. J. Weiss [1 ]
机构：
[1] Northwell Health,
[2] Donald & Barbara Zucker School of Medicine at Hofstra/Northwell,undefined
来源：
Journal of Gastrointestinal Cancer | 2025年 / 56卷 / 1期
关键词：
Pancreatic Cancer; Pancreatic Organoids; PDAC;
D O I：
10.1007/s12029-025-01164-5
中图分类号：
学科分类号：
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers. Surgical resection combined with appropriate chemotherapy currently offers the best chance for long-term survival and potential cure. However, effective treatment is hindered by the limited chemotherapy options and the absence of reliable clinical tools to guide chemotherapy selection. Patient-derived organoids (PDOs) have emerged as a promising technology with the potential in precision medicine for PDAC. This review provides an overview of pancreatic organoid genesis, explores the role of PDOs in elucidating PDAC biology within clinically relevant contexts, and concludes by examining current literature on the utility of PDOs as biomarkers for personalized treatment strategies.
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