Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives

被引：0

作者：

Junsi Luo ^{[1
]}

Yiteng Cui ^{[3
]}

Laijun Xu ^{[3
]}

Junyi Zhang ^{[1
]}

Jinhong Chen ^{[3
]}

Xumin Li ^{[5
]}

Bin Zeng ^{[3
]}

Zhiyuan Deng ^{[1
]}

Longquan Shao ^{[1
]}

机构：

[1] Southern Medical University,Stomatological Hospital, School of Stomatology

[2] Southern Medical University,Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering

[3] Central South University,Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology

[4] Stanford University School of Medicine,Institute for Stem Cell Biology and Regenerative Medicine

[5] Changsha Medical University,School of Stomatology

来源：

Journal of Nanobiotechnology | / 23卷 / 1期

关键词：

2D nanomaterial; Layered double hydroxides; Regenerative nanomedicine; Tissue engineering;

D O I：

10.1186/s12951-025-03448-1

中图分类号：

学科分类号：

摘要：

With the rapid development of nanotechnology, layered double hydroxides (LDHs) have attracted considerable attention in the biomedical field due to their highly tunable composition and structure, superior biocompatibility, multifunctional bioactivity, and exceptional drug delivery performance. However, a focused and comprehensive review addressing the role of LDHs specifically in tissue regeneration has been lacking. This review aims to fill that gap by providing a systematic and in-depth overview of recent advances in the application of LDHs across various regenerative domains, including bone repair, cartilage reconstruction, angiogenesis, wound healing, and nerve regeneration. Beyond presenting emerging applications, the review places particular emphasis on elucidating the underlying mechanisms through which LDHs exert their therapeutic effects. Although LDHs demonstrate considerable promise in regenerative medicine, their clinical translation remains in its infancy. To address this, we not only provided our insights into the personalized problems that arise in the application of various tissues, but also focused on discussing and prospecting the common challenges in the clinical translation of LDHs. These challenges include optimizing synthesis techniques, enhancing biosafety and stability, improving drug-loading efficiency, designing multifunctional composite materials, and establishing pathways that facilitate the transition from laboratory research to clinical practice.

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