Iron Porphyrins and Iron Salens as Highly Enantioselective Catalysts for the Ring-Expansion Reaction of Epoxides to Tetrahydrofurans

被引：0

作者：

Uluturk, Mehmet ^{[1
,2
]}

Gollu, Mehmet ^{[3
]}

Tilki, Tahir ^{[2
]}

Erturk, Erkan ^{[1
,4
]}

机构：

[1] TUBITAK Marmara Res Ctr, TR-41470 Gebze, Kocaeli, Turkiye

[2] Suleyman Demirel Univ, Dept Chem, TR-32260 Isparta, Turkiye

[3] Middle East Tech Univ, Dept Chem, TR-06531 Ankara, Turkiye

[4] Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkiye

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 12期

关键词：

EPOXIDATION; COMPLEXES; METAL; EMERGENCE; OXIDATION; SOLVENT; ROUTE;

D O I：

10.1021/acs.orglett.5c00767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iron porphyrins have been found to be efficient catalysts for the ring-expansion reaction of epoxides with alkenes to give the corresponding tetrahydrofurans; very low loadings (down to 1 mol %) are sufficient to achieve high yields (up to 98%). Additionally, an iron(III) salen complex based on the axially chiral 1,1-binaphthalene backbone has been shown to catalyze the reaction with high enantioselectivity (e.g., 92% ee for calyxolane A).

引用

页码：3083 / 3088

页数：6

共 49 条

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